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Replicating fork, DNA

Registiy of Mass Spectral Data, 412 Replication (DNA). 1106-1107 direction of, 1107 error rate during. 1107 lagging strand in, 1107 leading strand in, 1107 Okazaki fragments in, 1107 replication fork in, 1107 Replication fork (DNA), 1107 Reserpine, structure of, 65 Residue (protein), 1027 Resist, photolithography and, 505-506... [Pg.1314]

Removal of positive supercoils ahead of advancing replication forks DNA topoisomerase II (DNA gyrase) DNA topoisomerase II... [Pg.19]

Correct answer = C. Fluoroquinolones, such as ciprofloxacin, inhibit bacterial DNA gyrase—a type II DNA topoisomerase. This enzyme catalyzes the transient breaking and rejoining of the phosphodiester bonds of the DNA backbone, to allow the removal of positive supercoils during DNA replication. The other enzyme activities mentioned are not affected. Primase synthesizes RNA primers, helicase breaks hydrogen bonds in front of the replication fork, DNA polymerase I removes RNA primers, and DNA igase joins Okazaki fragments. [Pg.412]

Because only one strand can serve as a template for synthesis in the 5 to 3 direction (the template goes in the 3 to 5 direction, because the double helix is antiparallel), only one strand, the leading strand, can be elongated continuously. Ahead of the replication fork, DNA gyrase (topoisomerase II) helps unwind the DNA double helix and keep the double strands from tangling during replication. [Pg.155]

Branzei, D. and Foiani, M. (2007) Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair, 6, 994-1003. [Pg.234]

There are at least three classes of DNA polymerases, based on their functional differences. In E. coli, DNA pol III is required for DNA synthesis at the replication fork, DNA pol I fills in gaps in the lagging strand, and DNA pol... [Pg.628]

Formation of replication fork DNA polymerases use single-stranded DNA (ssDNA) as templates. This involves the unwinding (opening) of the DNA duplex. Cir-... [Pg.446]

DNA helicase and replication fork DNA helicase unwinds the DNA double hehx at the Y-shaped replication fork ... [Pg.137]

Replication fork (Sechon 28 9) Point at which strands of double helical DNA separate... [Pg.1292]

Lagging strand (Section 28.10) In DNA replication, the strand that grows away from the replication fork. [Pg.1287]

Replication fork (Section 28.3) The point of unraveling in a DNA chain where replication occurs. [Pg.1249]

Camptothecins. Figure 3 Conversion of reversible Topi -DNA cleavage complexes into DNA damage by collision of a replication fork (the DNA polymerase complex is not shown). [Pg.316]

Figure 36-17. The generation of "replication bubbles" during the process of DNA synthesis. The bidirectional replication and the proposed positions of unwinding proteins at the replication forks are depicted. Figure 36-17. The generation of "replication bubbles" during the process of DNA synthesis. The bidirectional replication and the proposed positions of unwinding proteins at the replication forks are depicted.
DNA synthesis occurs in both directions at each of the rep-licating forks. Once a DNA strand has been primed, synthesis toward the replicating fork can be visualized as continuous. Growth of the opposite,... [Pg.227]

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See also in sourсe #XX -- [ Pg.452 ]



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