REPERFUSION SECONDARY INJURY PREVENTION

ELISSAVET KARDAMI, KAREN DETILLIEUX, SARAH JIMENEZ, PETER CATTINI 

Myogenesis via stem cell recruitment/survival amplification 

Capillary generation Vessel enlargement Collateral development 

Improved Myocyte Survival Independent of Mitogenic Potential 

LONG-TERM BENEFICIAL EFFECTS Dependent on Mitogenic Potential 

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The ideal anticoagulant drug would prevent pathologic thrombosis and limit reperfusion injury, yet allow a normal response to vascular injury and limit bleeding. Theoretically this could be accomplished by preservation of the TF-VIIa initiation phase of the clotting mechanism with attenuation of the secondary intrinsic pathway propagation phase of clot development. At this... 

Acute renal failure secondary to ischemia-reperfusion or nephro-toxins represents a major cause of morbidity and mortality in hospitalized patients, particularly in the intensive care unit setting. The proximal tubule region of the nephron suffers the most damage in acute renal injury and is therefore the target site of therapeutic interventions. While several experimental therapies have been attempted to prevent or hasten recovery from acute renal injury,... 

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