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Renal stones acetazolamide

Acetazolamide, others Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2 Reduces reabsorption of HC03 in the kidney, causing self-limited diuresis hyperchloremic metabolic acidosis reduces body pH, reduces intraocular pressure Glaucoma, mountain sickness, edema with alkalosis Oral and topical preparations available duration of action 8-12 h Toxicity Metabolic acidosis, renal stones, hyperammonemia in cirrhotics... [Pg.341]

Mackenzie AR. Acetazolamide-induced renal stone. J Urol 1960 84 453-455. [Pg.349]

Contraindications to the use of methazolamide are the same as those associated with the use of acetazolamide. Methazolamide, however, can be used more safely in patients with a history of kidney stones or renal impairment. Patients with COPD may tolerate methazolamide better than acetazolamide, because the metabolic acidosis is less pronounced. [Pg.164]

One must keep in mind that older patients with uric acid kidney stones also may have hypertension, congestive heart failure, or renal insufficiency, and obviously should not be exposed to overload with aUcalinizing sodium salts or unlimited fluid intake. Acetazolamide, a carbonic anhydrase inhibitor, produces rapid and effective urinary alkalinization and sometimes is used in conjunction with alkali therapy. When a 250-mg dose of acetazolamide is given at bedtime, the excretion of an acidic urine in the early morning hours is avoided. The usual tachyphylaxis (rapid tolerance) to this drug is obviated by a daily repletion dose of bicarbonate. [Pg.1709]

The administration of acetazolamide has been reported to be associated with hematuria and acute renal failure [70-76]. In each of these patients, intratubular obstruction caused by crystal deposition, stone formation, and the presence of blood clots was either found or suspected. Relief of the obstruction and discontinuation of the drug resulted in the reversal of the renal failure. Volume expansion and mechanical relief of obstruction have been advocated in the treatment of this condition. However, the administration of sodium bicarbonate is controversial, since it may predispose to the development of calcium phosphate stones [77, 78]. [Pg.343]


See other pages where Renal stones acetazolamide is mentioned: [Pg.274]    [Pg.1715]   
See also in sourсe #XX -- [ Pg.182 ]




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