Osteomalacia tumor-induced

Renal elimination of phosphorus is regulated by PTH, calcitriol, growth hormone, insulin, and insulin-like growth factors. While the above-mentioned hormones show a number of other effects, the existence of a hormone affecting selectively the extracellular concentration of phosphorus is expected. The task of this hormone with phosphaturic effect has been speculated about from the beginning of the 1990s. It was named phosphatonin, and its increased concentration is found especially in patients with osteomalacia (tumor-induced osteomalacia, X-linked hypophosphatemic rickets, epidermal nevus). The phosphaturic effect of... 

Tumor-induced osteomalacia (oncogenic hypophosphatemic osteomalacia) is also characterized by excessive urinary excretion of phosphate, and hence hypophosphatemia and low circulating calcitriol. Removal of the tumor results in normalization of phosphate excretion and... 

Kumar R (2000) Tumor-induced osteomalacia and the regulation of phosphate homeostasis. Bone 27, 333-8. 

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