Removal of Leukocytes from Blood Products

Membranes for Removal of Leukocytes from Blood Products [Pg.110]

Leukocyte-depleted blood products, particularly red blood cell concentrates, are clinically used to avoid negative side effects in recipients after transfusion. Possible leukocyte-associated post-transfusion complications include human leukocyte antigen alloimmunization, graft-versus-host disease, platelet refractoriness, and transmission of viruses. Amongst the various existing techniques for the selective removal of leukocytes from blood, filtration has become a popular method, because of its convenience and lowcosts. Leukocyte filters have been specially developed for the purpose they generally consist of fibrous materials made of Nylon, PAN, cotton wool, cellulose acetate,or polyester. Currendy available filters [Pg.110]

Adsorber MW Cut-Off or Pore Diameter pm Leukocyte Concentration Media X10, cfu/mL Volume, mL Time- Average Ref. [Pg.111]

Cfu -cel I form ing un it RBC - concentrate of red blood cel Is containing granulocytes, lymphocytes and monocytes. [42] Microporous polyurethane filters unmodified and modified (adsorption technique) with PEI 600 (MW40000-60000) 0.0982 m flowrate a2.4 mL/min, b 12 mL/min Commercial Optima Cellselect leukocyte filters composed from poly(ethyleneterephthalate) (NPBI, Emmer-Compascuum, Netherlands) unmodified and modified with PEI 0.0982 m flow rate 2.4 mL/min. [Pg.111]

Freitag R, Tennikova T High performance membrane adsorber chromatography (HPMC) for protein isolation. In Aboul-Enein HY, ed. Analytical and Preparative Separation Methods for [Pg.112]

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