Release characteristics, effect polymerization

Figure 4. Effect of polymerization conditions on the release characteristics of the insulin/poly(acrylic acid) resin system.

Polymerized liposomes are being actively investigated for their use in controlled release applications such as drug delivery and biosensors.(24) At present, in order to obtain liposomes which have the release characteristics required for a specific need, the amphiphiles used to construct the liposome as well as the precise mixture of amphiphiles required must be designed and synthesized from start each time. This is a time consuming and expensive process. One of our main objectives in this research is to design a series of liposomes constructed from diacetylenic and short chain spacer lipids with predictable leak rates which could be utilized in controlled release applications. In order to accomplish this goal, it was necessary to characterize both the effect of spacer lipid on microstructure formation properties and to determine the methods that could be used to... 

In Figure 2 the variation of the concentration with the time is reported for controlled release systems. The difference with traditional systems is evident a controlled release system minimizes concentration variations of the drug and provides improved therapeutic action by enhancing the drug s longevity and effectiveness in the body. These characteristics are by entrapping the drug in a polymeric matrix, from whidi it is released by diffiision control. 

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