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Related Amyloidosis

Senile systemic or age-related amyloidosis (SSA) results from the misfolding of wild-type transthyretin protein. Age-related amyloidosis occurs in systemic and localized (isolated atrial amyloid, senile aortic amyloidosis) forms. Elderly men are almost uniformly involved. Ng et al. (49) recently reported 18 SSA patients ranging in age from 67 to 86 years. [Pg.799]

Kunze (50) examined autopsied lung and heart tissue from 340 octogenarians, finding two predominant patterns of amyloid deposits in 49 cases (/) combined vascular and alveolar-septal or (ii) isolated alveolar-septal disease. Typically concurrent heart and lung involvement occurred. The incidence of lung amyloid deposits increased with age, from 2% of cases 80 years old to 10% in cases 80 to 84 years old, and 20% in those older than 85 years. Alveolar-septal deposition always accompanied vascular deposits. Bronchial walls were never involved. [Pg.799]

Pitkanen et al. (51) performed detailed histologic evaluations of 24 organs harvested at autopsy in 13 patients with SSA. In all cases, nodular amyloid deposits occurred in alveolar septae and vessel walls. In advanced cases, amyloid deposits were also detected in the lamina propria of bronchi. Westermark et al. (52) examined 33 Swedes with advanced senile cardiac amyloidosis at autopsy, confirming the ubiquitous presence of alveolar septal amyloid in these cases. [Pg.799]

Three autopsy series including 33 Swedish SSA cases (52), 13 Swedish and American cases (51), and 50 lung-restricted dissections (50) did not report any pleural amyloid deposition. [Pg.799]

A direct correlation between years of dialysis, prolonged exposure to p2 microglobulin (B2M), and dialysis-related amyloidosis (DRA) exists. In 54 [Pg.799]

Creutzfeldt-Jakob disease (CJD) Alzheimer s disease (AD) Hemodialysis-related amyloidosis Primary systemic amyloidosis Secondary systemic amyloidosis Familial amyloid polyneuropathy I Familial amyloid polyneuropathy III Cerebral amyloid angiopathy Finnish hereditary systemic amyloidosis Type II diabetes Injection-localized amyloidosis Medullary thyroid carcinoma Atrial amyloidosis... [Pg.199]

Joy T, Wang J, Hahn A, Hegele RA (2003) APOA1 related amyloidosis a case report and literature review. Clin Biochem 36 641-645... [Pg.546]

Maury, C.P. 1991. Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin. J Clin Invest. 87 1195-9. [Pg.67]

Maury, C.P., M. Liljestrom, G. Boysen, T. Tornroth, A. de la Chapelle, and E.L. Nurmiaho-Lassila. 2000. Danish type gelsolin related amyloidosis 654G-T mutation is associated with a disease patho-genetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type). J Clin Pathol. 53 95-9. [Pg.67]

Paunio, T., H. Kangas, O. Heinonen, M.H. Buc-Caron, JJ. Robert, S. Kaasinen, I. Julkunen, J. Mallet, and L. Peltonen. 1998. Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis. J Biol Chem. 273 16319-24. [Pg.67]

Hemodialysis-related amyloidosis fS2-microglobulin (fi2m) Systemic... [Pg.1602]

Alzheimer s Disease Spongiform encephalopathies Primary systemic amyloidosis Secondary systemic amyloidosis Familial amyloidotic polyneuropathy I Senile systemic amyloidosis Hereditary cerebral amyloid angiopathy Haemodialysis-related amyloidosis Familial amyloidotic polyneuropahy II Finnish hereditary amyloidosis Type n diabetes... [Pg.2095]

Saito A, Gejyo F. Current clinical aspects of dialysis-related amyloidosis in chronic dialysis patients. Ther Apher Dial 2006 10 ... [Pg.121]

Table 2 compares the clinical data in our patients with heroin related amyloidosis (n=24) and heroin related FSGS (n=30) [50]. Most patients with renal amyloidosis had exhausted their intravenous access for drug abuse and resorted to subcutaneous "skinpopping". Almost all patients used heroin, some mixed with cocaine, and two patients reportedly abused only pentazocine and tripelennamine [64]. All patients had chronic dermal ulcerations and suppurative skin infections. [Pg.600]

When tested, the amyloid is of the secondary type, amyloid A protein. Serum amyloid A, an acute phase reactant produced by hepatocy tes, circulates complexes to high density lipoprotein and is cleaved into smaller fragments which subsequently polymerize into the P pleated sheet configuration of amyloid [23, 35]. In heroin related amyloidosis, the amyloid is heavily distributed in the tubular basement membranes, vessel walls, and interstitium as well as the glomeruli. There is greater tubular basement membrane and interstitial amyloid deposition in drug related renal amyloid than in secondary renal amyloid unrelated to heroin abuse... [Pg.388]

The use of high-flux membranes gained significant support in 1985 when Geyjo et al. [343] conclusively estahfished the link between the accumulation of P2M and a compfication of long-term dialysis called dialysis-related amyloidosis (DRA). As kidney failure progresses, P2M concentration in the extracellular compartments increases, often to levels... [Pg.568]

Villanueva, J., Hoshino, M., Katou, H., et al. (2004) Increase in the conformational flexibility of p2-microglobiflin upon copper binding A possible role for copper in dialysis-related amyloidosis. Protein Sci, 13 (3), 797-809. [Pg.164]

Suzuki M, Betsuyaku T, Kojima T, et al. Pleural involvement of dialysis-related amyloidosis. Intern Med 2005 44(6) 628-631. [Pg.805]

Ueda M, Ando Y, Haraoka K, et al. Aging and transthyretin-related amyloidosis pathologic examinations in pulmonary amyloidosis. Amyloid 2006 13(1) 24—30. Ng B, Connors LH, Davidoff R, et al. Senile systemic amyloidosis presenting with heart failure a comparison with light chain-associated amyloidosis. Arch Intern... [Pg.806]

Dzido G, Sprague SM (2003) Dialysis-related amyloidosis. Urol Nefrol 55 121-129... [Pg.182]

Kay J, Benson CB, Lester S et al (1992) Utility of high-resolution ultrasound for the diagnosis of dialysis-related amyloidosis. Arthritis Rheum 35 926-932... [Pg.327]

Malghem J, Vande Berg B, Jadoul M et al (1996) Sonographic findings in patients with dialysis-related amyloidosis. AJR Am J Roentgenol 166 153-156... [Pg.328]

Mayerhoefer ME, Breitenseher MJ, Roposch A et al (2005) Comparison of MRI and conventional radiography for assessment of acromial shape. AJR Am J Roentgenol 184 671-675 McMahon LP, Radford J, Dawborn JK (1991) Shoulder ultrasound in dialysis related amyloidosis. Clin Nephrol 35 227-232... [Pg.328]

Sommer R, Valen GJ, Ori Y et al (2000) Sonographic features of dialysis-related amyloidosis of the shovdder. J Ultrasound Med 19 765-770... [Pg.330]

See other pages where Related Amyloidosis is mentioned: [Pg.278]    [Pg.101]    [Pg.108]    [Pg.260]    [Pg.268]    [Pg.142]    [Pg.105]    [Pg.388]    [Pg.223]    [Pg.9]    [Pg.50]    [Pg.70]    [Pg.578]    [Pg.220]    [Pg.378]    [Pg.799]    [Pg.627]    [Pg.334]    [Pg.206]    [Pg.183]    [Pg.534]    [Pg.499]   


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