Regulatory Patterns for Paralog Proteins

6 Evolution of Protein Wrapping and Implications for the Drug Designer 

Ensembl ID Family size Swiss prot ID Gene name PDB ID 

To determine the dosage sensitivity we calculated the packing deficiency of each gene-encoded protein based on its PDB coordinates, if available. Otherwise, packing deficiency was determined based on homology-threaded structure coordinates adopting as templates PDB-reported paralogs [19]. The input for the computation consists of the set of constraints applied to the spatial structure of the amino acid sequence to be modeled and the output is the 3D structure that best satisfies these constraints. 

2 Wrapping Deficiency Causes Dosage Imbalance and Regulation Dissimilarity 

To assess the selection pressure imposed by dosage imbalance we first consider an exhaustive set of 457 non-singleton human gene families with paralog co-expression at the mRNA level rj 0, = family average. This condition is essential 

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