Dosage imbalance

The next two sections are devoted to provide further evidence in support of the claim that protein wrapping quality is a determinant of dosage sensitivity while upholding the view that resilience to dosage imbalance is achieved in humans by diversifying miRNA regulatory patterns across paralogs. 

Wrapping Deficiency Causes Dosage Imbalance and Regulation Dissimilarity... 

To assess the selection pressure imposed by dosage imbalance we first consider an exhaustive set of 457 non-singleton human gene families with paralog co-expression at the mRNA level < rj > > 0, <> = family average. This condition is essential... 

These results reveal that the human capacitance to dosage imbalance is in part required due to the inefficiency of the selection pressure on duplicate genes, precluding sufficient differentiation over the evolutionary times of the latest speciations, thereby maintaining an evolutionarily related dosage imbalance. 

The results of Fig. 6.3 imply that miRNA target dissimilarity across paralogs may be assimilated to a capacitance to dosage imbalance effects arising from gene... 

Fernandez A, Chen J (2009) Human capacitance to dosage imbalance coping with inefficient selection. Genome Res 19 2185-2192... 

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