Dosage sensitivity

The experimental evidence for this scenario, mentioned at the outset of this section, is less compelling since it is harder to control this sort of dosage-sensitive STM experiment than a Monte Carlo simulation. (Specifically, it problematic to convert from CO dosage to the evolution time from initial instability the analysis would be better if the surface could be instantaneously de-oxidized.) From an earlier examination of the terrace-width distribution for Ag(110)2Y—>[001], Ozcomert et al. (1993) concluded that to a good approximation the step-step interactions were purely entropic repulsions (by finding a good fit to a free-fermion form (Jobs et al, 1991)). (But see also Pai et al (1994) for remarkable behavior under different conditions.) From the relationship (Bartelt el a/., 1992)... 

The next two sections are devoted to provide further evidence in support of the claim that protein wrapping quality is a determinant of dosage sensitivity while upholding the view that resilience to dosage imbalance is achieved in humans by diversifying miRNA regulatory patterns across paralogs. 

To determine the dosage sensitivity we calculated the packing deficiency of each gene-encoded protein based on its PDB coordinates, if available. Otherwise, packing deficiency was determined based on homology-threaded structure coordinates adopting as templates PDB-reported paralogs [19]. The input for the computation consists of the set of constraints applied to the spatial structure of the amino acid sequence to be modeled and the output is the 3D structure that best satisfies these constraints. 

Papp B, Pal C, Hurst LD (2003) Dosage sensitivity and the evolution of gene families in yeast. Nature 424 194-197... 

FLUORIMETRIC DETERMINATION OE KETOROLAC AND KETOPROEEN IN DOSAGE EORMS USING TERBIUM SENSITIZED LUMINESCENCE... 

Stomach and intestinal ulcers. 8.3 Side effects Occasionally, headaches may be caused in people who are sensitive to bitter substances. 8 4 Dosage and manner of use Boiling water (ca. 150 ml) is poured over two tea-spoonfuls of the Lea, covered and allowed to draw for 5 10 min, and then passed through a tea strainer. If not otherwise pre.scribed, a cup of the fresh and 8.2 Dosage and manner of use Boiling water fca. 150 ml) is poured over a table-spoonful of the tea, covered and allowed to draw for ca. 10 min., and then passed through a tea strainer. 11 not otherwise prescribed, a cup of the freshly prepared tea is drunk warm several times a day between meals. 8.3 Note Store protected from light and moisture. 

The decomposition of KMn04 is sensitive to pre-irradiation [899] by UV [396], X-rays, 7-rays, protons and neutrons. The effects of such pretreatment, which increase with dosage, are to reduce the induction period... 

Administration of zafirlukast and aspirin increases plasma levels of zafirlukast, When zafirlukast is administered with warfarin, there is an increased effect of the anti coagulant. Administration of zafirlukast and theophylline or erythromycin may result in a decreased level of zafirlukast. Administration of montelukast with other drugs has not revealed any adverse responses. Administration of montelukast with aspirin and NSAIDs is avoided in patients with known aspirin sensitivity. Administration of zileuton with propranolol increases the activity or the propranolol with theophylline increases serum theophylline levels and with warfarin may increase prothrombin time (PT). A prothrombin blood test should be done regularly in the event dosages of warfarin need to be decreased. 

Because some patients are more sensitive to side effects with digoxin, the dosage is selected carefully and adjusted as the clinical condition indicates. Adverse reactions were more common and severe in past years before careful attention to weight, renal function, and the concurrent administration of certain medications was given. The incidence and severity of digoxin toxicity has decreased significantly in recent years. 

Older adults are particularly sensitive to the hypotensive effects of nitroprusside. To minimize the hypotensve effects the drug is initially given in lower dosages Older adults require more frequent monitoring during the administration of nitroprusside. 

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