Regulations select agent

The first and best-studied allosteric site on GPCRs is that on the muscarinic receptor [9,10,12,19,20]. For the five subtypes of these receptors that have been cloned and pharmacologically defined as Mi to M5, various agents have been identified that allosterically regulate selectively these... 

For the most part the selective Class III agents appear to act by inhibition of one or more repolarizing potassiuim currents, especially the delayed rectifier (/k) and/or the inward rectifier (/ki). Less selective agents generally affect sodium currents, as well as potassium currents, which translates to Class I (conduction-slowing) activity. Additional work still needs to be done to increase our understanding of the currents and channels involved in regulation of APD. Care must be taken to evaluate species differences, tissue dif-... 

Cyclohexamide is used as a fungicide, plant growth regulator, and as protein synthesis inhibitor. This is also used in laboratory media as a selective agent to permit isolation of pathogenic and nonpathogenic fungi. 

Swamy et al. ° used human HT-29 colon cancer cells to study the effectiveness of lovastatin and celecoxib, individually or in combination on the induction of apoptosis in human HT-29 colon cancer cells. They also studied the modulatory effect of lovastatin and celecoxib on lamin B levels, caspase-3 activity and expression in relationship to apoptosis in colon cancer cell lines. Importantly, their results showed that agents with different modes of action, when utilized in combinations, will induce apoptosis synergistically by enhancing caspase-3 activities. These authors concluded that the regulation of apoptosis is enhanced by selective agents such as lovastatin and celecoxib combinations for colon cancer prevention. 

Robins RJ, Hamill JD, Parr AJ, Smith K, Walton NJ, Rhodes MJC (1987) Potential for use of nicotinic acid as a selective agent for isolation of high nicotine-producing lines of Nicotiana rustica hairy root cultures. Plant Cell Rep 6 122-126 Robins RJ, Parr AJ, Walton NJ, Rhodes MJC (1990) Factors regulating tropane-alkaloid production in a transformed root culture of a Datura Candida x D. aurea hybrid. Planta 181 414-422... 

A select agent or toxin regulated by the Centers for Disease Control and Prevention under 42 CFR Part 73 or the... 

Violations of these Select Agent regulations may be deemed criminal and subject to investigation by the Federal Bureau of Investigation and prosecution by the U.S. Department of Justice. 

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