Regulation of the Heat Shock Response

Dubois, M.F., Mezger, V., Morange, M., Ferrieux, C., Lebon, P., Bensaude, O. (1988). Regulation of the heat-shock response by interferon in mouse L cells. J. Cell Physiol. 137, 102—109. 

Airaksinen, S., C.M. Rabergh, A. Lahti, A. Kaatrasalo, L. Sistonen and M. Nikinmaa. Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio. Comp. Biochem. Physiol. 134A 839-846, 2003. 

Schmidt, J.A. Abdulla, E. (1988). Down regulation of IL-ip biosynthesis by inducers of the heat shock response. J. Itmnunol. 141, 2027—2034. 

In contrast to the heat shock response, there is only limited information on the regulation of the cold shock response, and this exists only for E. coli. Most publications deal with the regulatory role of CspA after a temperature downshock. 

Morimoto, R.I. (1998). Regulation of the heat-shock transcriptional response Cross talk between a family of heat-shock factors, molecular chaper-... 

Cellular responses to metal ions include changes of patterns of gene expression. Many of these changes are non-specific shock effects for example, subsets of the heat shock proteins are synthesised in response to Cd (Czarnecka et al., 1984 Lin et al., 1984 Delhaize et al., 1989). However, some mRNAs are specifically induced by Cd (Delhaize et al., 1989). Thus, by examining metal-regulated gene expression, whether specific or non-specific, it may be possible to determine the relative roles of proteins and polypeptides specific to metal homeostasis and metal tolerance, as opposed to functions involved in general stress responses. 

Boy-Marcotte, E., Lagniel, G., Perrot, M., Bussereau, F., Boudsocq, A., Jacquet, M., and Labarre, J. 1999. The heat shock response in yeast Differential regulations and contributions of the Msn2p/Msn4p and Hsflp regulons. Mol. Microbiol. 33, 274—283. 

Fig. 10.2 Synthesis and regulation of qrtoplasmic heat shock proteins. Plants mount resistance to heat shock (HS) stress by eliciting specific metabolic adjustments, together referred to as heat shock response (HSR). The temperature for the induction of the HSR varies amongst different plant species, but an increase of 5-10°C over and above the ambient temperature is sufficient to elicit HSR. Heat shock proteins (Hsp) are synthesized in the cytoplasm using hsp mRNA transcribed in the nucleus. Most Hsp act as chaper-...

During microspore embryogenesis the up regulation of the Head Shock Protein (HSP) genes is observed, not only in response to heat stress but also other stresses applied on... 

Many appear to act as chaperonins (see Molecular chaperones) in bacterial cells, the cytoplasm of eukaryotic cells, and mitochondria. The 1 70 family in i -ticular appears to chaperone the insertion of proteins into membranes. [O. Bensaude et al. Nature 305 (1983) 331-332 E. A. Craig The heat shock response CRC Cril. Rev. Biochem. 18 (1986) 239-280 CWu Heat Shock llanscription Factors Structure and Regulation Amu. Rev. Cell Dev. Biol. 11 (1995) 441-469]... 

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