Regulation of phospholipid head-group composition

how is phosphohpid homeostasis maintained Control of the individual enzymes at the level of activity by feedback regulation appears a more probable mechanism. Perturbations in the ratio of phospholipids were attempted experimentally by the activation of phospho-glycerol transferase I (mdoB). This enzyme, involved in MDO synthesis, catalyzes the transfer of glycerol phosphate from PtdGro to the extracellular arbutin (4-hydroxyphenyl- 

0-P-D-glucoside). Treatment with arbutin (an MDO substrate analog) causes a 7-fold increase in the rate of PtdGro synthesis without a concomitant increase in PtdGroP synthase proteins or significant changes in membrane phospholipid composition. Thus, PS synthase 

Coordinate regulation of fatty acid and phospholipid synthesis with macromolecular biosynthesis 

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