Regulation of haematopoiesis by CSFs

It is believed that all blood cells arise from the division and differentiation of multipotent stem cells. These stem cells have considerable capacity for self-renewal by cell division but may also differentiate into progenitor cells of lymphocytic or myeloid lineages (see Fig. 2.1). Experiments with colony- 

Component Other name Native protein (glycoprotein) (kDa) Recombinant protein (non-glycosylated) (kDa) Colonies stimulated Chromosomal location Produced by 

G-CSF CSF-/J 19.6 18.8 neutrophils, BFU-E 17ql 1.2-21 endothelial cells, macrophages, fibroblasts 

GM-CSF CSF-a 22 14.3 neutrophils, monocytes, neutrophil/monocyte, eosinophils, BFU-E 5q23-31 T lymphocytes, fibroblasts, epithelial cells, endothelial cells, macrophages 

M-CSF CSF-1 70-90 (dimer) 21 (subunit) monocytes lpl3-21 macrophages, fibroblasts, endothelial cells 

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