Regeneration Hypertrophy

As another application of LCM to CNS injury, Ho et al. (ref. 533) studied the affinity of LCM to the site of a localized (thermal) brain injury. It had been well documented that in response to injury in the CNS, astrocytes are activated which is accompanied by an increased content of GFAP, hypertrophy, and hyperplasia (ref. 679-683). (This process of gliosis (ref. 682) results in scar formation it has been speculated that the scar may inhibit axonal regeneration (ref. 684)) (ref. 533). Ho et al. observed that the influx of LCM began at the time when GFAP-positive cells began to appear. It seemed likely that LCM are initially attracted to the reactive astrocytes, but subsequently the LCM were found to be excluded... 

Kim I, Mogford JE, Witschi C, Nafissi M, Mustoe TA. Inhibition of prolyl 4-hydroxylase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair and Regeneration 2003, 11, 368-372. 

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Philippou, A., Halapas, A., Maridaki, M. et al. 2007. Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. / Musculoskelet Neuronal Interact 7(3) 208-18. 

Tatsumi, R. 2010. Mechano-hiology of skeletal muscle hypertrophy and regeneration Possible mechanism of stretch-induced activation of resident myogenic stem cells. Anim Sci /81(l) ll-20. 

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