Regenass

Reaction calorimetry is a technique which uses data on the rate of heat evolution or consumption to evaluate the thermokinetic reaction characteristics needed for reactor scale-up and/or optimization and safety. Since the late seventies, the application of this technique has been steadily growing and reaction calorimeters are now commercially available. Probably the first commercial reactor calorimeter was developed by CIBA-GEIGY (Bench Scale Calorimeter BSC) (see Beyrich et al, 1980 and Regenass et al., 1978, 1980, 1983, 1984, 1985, 1997))... 

Figure 5.4-54. Causes of thermal runaways (adapted from Regenass, 1984b).

Regenass, W., 1978, ACS Syinpos. Ser. 65, Chemical Reaction Engineering, Houston, 37. Regenass, W., 1980, Proc. Vlth hit. Conf. on Thermal Analysis, Bayreuth, July, 561. 

Regenass, W., 1984b, Proc. Sympos. Protection of Exothermic Reaction, Chester, April. Regenass, W., 1985, Thermochimica Acta 95, 351. 

Schnurr B, Ahrens T, Regenass U (2006) Optical assays in drug discovery In Taylor JB, Triggle DJ (eds) Comprehensive medicinal chemistry II. Elsevier, Oxford, Sect 3.27... 

Buchdunger E, Mett H, Trinks U, Regenass U, Muller M, Meyer T, Beilstein P, Wirz B, Schneider P, Traxler P (1995) Clin Cancer Res 1 813... 

Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, Lydon N (1995) Proc Natl Acad Sci USA 92 2558... 

Regenass [160] mentions the factors, as listed below, that can lead to a runaway. When any two or more of these factors are present, there is a potential for thermal runaway ... 

Regenass, W., "Safe Operation of Exothermic Reactors," technical paper, Ciba-Geigy Limited, Basel, Switzerland (1984). 

Bourne, J. R., F. Brogli, F. Hoch, and W. Regenass, "Heat Transfer from Exothermically Reacting Fluids in Vertical Unstirred Vessels—I. Temperature and Fluid Fields," Chem. Eng. Sci., 42,2183 (1987). 

Regenass, W., "Thermische Methoden zur Bestimmung der Makrokinetik" ("Thermal Methods to Determine Macro-Kinetics"), Chimia, 37,430 (1983). 

Regenass, W. Medium-scale heat flow calorimeter for measurement of heat release and cooling requirements under realistic reaction conditions. 

Meyer T, Regenass U, Fabbro D, Alter E, Rdsel J, Muller M, Carvatti G, Matter A (1989) A derivative of staurosporine (CGP 41251) shows selectivity for PKC inhibition and in vitro antiprolif erative as well as in vivo antitumor activity. Int J Cancer,43 851-856... 

PNA2558 E. Buchdunger, J. Zimmermann, H. Mett, T. Meyer, M. Muller, U. Regenass, and N. B. Lydon, Proc. Natl. Acad. Sci. USA,... 

Stability estimates for the stirred tank reactor (with W. Regenass). Chem. Eng. ScL 20, 60-66 (1964). 

In fact, the simple detection device used in the laboratory was unable to detect the exothermal reaction At laboratory scale, the heat exchange area is larger by about two orders of magnitude (see Section 2.4.1.2), compared to plant scale. Hence the heat of reaction could be removed without detectable temperature difference, whereas at plant scale the same exotherm could not be mastered. This incident enhanced the necessity of a reaction calorimeter and promoted the development of the instrument, which was under development at this time by Regenass [1], Later, it became a commercial device (RC1). 

Regenass, W. (1997) The development od Stirred-Tank Heat Flow Calorimetry as a Tool for Process Optimization and Proces safety. Chimia, 51,189-200. 

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