Reference cell lines section preparation

Formalin-fixed and paraffin-processed sections from commercially prepared composite cell line block comprising the human breast carcinoma cell lines SK-BR-3, MDA-MB-453, MDA-MB-175, and MDA-MB-231, have been used consistently for the past 5 years for HER2 IffC EQA evaluation. More recently, the same composite cell line block reference material has been introduced for EQA evaluation of HER2 ISH testing of breast cancer. The principles and protocols developed and established for running of these two schemes have been recently described by Miller et al.13 and Bartlett et al.14... 

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