Redundant genes

Redundant gene family Single gene mutation Redundant gene family Small molecule antagonist... 

Figure 18 Classical" genetics (a) versus chemical genetics (b) in the presence of gene redundancy. Single genetic knock-outs of one gene from a redundant gene family might lack a phenotypic response because other family members will functionally substitute its role. In contrast, a small molecule...

Mizoguchi, X, Wheatley, K., Hanzawa, Y, Wright, L., Mizoguchi, M., Song, H.R., Carre, LA., and Coupland, G., LHY and CCAl are partially redundant genes required to maintain circadian rhythms in Arabidopsis, Dev. Cell, 2, 629, 2002. 

Very low-density lipoprotein receptor ( VLDLR) and APOE receptor-2 ( APOER2) are two gene family members with redundant functions. They are expressed in neurons of the developing brain and act as cell... 

Armando Aranda The idea is that in a very simple system like yeast, if you have two genes doing the same function, and then one of the genes should be subject to continuous mutation by drift, because it can t be seen by natural selection. And the amazing thing is that it is not the case that such genes, which are redundant, are subject to random mutation. That s one of the big issues now. 

Inactivation of the tau gene by homologous recombination results in mice that are largely normal [22], indicating that tau is a nonessential protein. This may reflect functional redundancy. Thus, mice doubly deficient in tau and the microtubule-associated protein MAP IB exhibit nervous system defects that are more severe than those in the MAP IB single knockout line. 

Heber, S., Herms, J., Gajic, V. et al. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci. 20 7951-7963,2000. 

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