Recombinant vector vaccines adenovirus-based vectors

Graham, F.L. and Prevec, L. (1992). Adenovirus-based expression vectors and recombinant vaccines. In Vaccines New Approaches to Immunological Problems. R.W. Ellis, ed. (Boston Butterworth-Heinemann), pp. 363 390. 

The ability of two soluble chitosan formulations (chitosan and glycol chitosan) to improve the immunogenicity of an intranasaUy administered replication-defective human adenovirus type 5 expressing BoHV-1 glycoprotein D-based vaccine was investigated in cattle (Vila et al. 2004). It was reported that soluble formulation of glycol chitosan has promising potential use as an intranasal adjuvant for recombinant viral vector vaccines in cattle. 

Most vaccine vectors developed to date are viral based, with poxviruses (as well as picorna viruses and adenoviruses) being used most. In general, such recombinant viral vectors elicit both... 

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