Recognizing molecule

Walters, W.P., Ajay, and Muegko, M.A. Recognizing molecules with drug-like properties. Curr. Opin. Chem. Biol. 1999, 3, 384-387. 

T-cell receptor A protein on the surface of T-lymphocytes that recognizes molecules of MHC. 

Because the adaptive immune response requires the generation of such broad diversity in recognition capabilities, it also recognizes molecules found in the body of the host itself. The self-directed immune response can potentially cause autoimmune disease. In an effort to avoid this harm, the body carefully shapes, regulates, and controls the adaptive immune response. These mechanisms are described in the second half of the chapter. 

However, there are certain regularities. Typically, the process of molecular recognition is characterized by a possibly and often markedly asymmetric duality, where the roles of the recognizer molecule A and the recognized molecule B can be interchanged. 

Recently, the author s group developed another aminoacylation method using PNA [18] as a tRNA-recognizing molecule (Fig. 5.1-5) [19]. An amino acid thioester was linked through a spacer to a 9-mer PNA that is complementary to the 3 region of a tRNA. When the PNA was hybridized with the tRNA, the amino acid thioester comes dose to the 3 OH group of the tRNA, provided the... 

Cholesterol is one of the most highly recognized molecules in human biology, in part because of a direct relationship between its concentrations in blood and tissues and the development of atherosclerotic vascular disease Cholesterol, which is transported in the blood in Upoproteins because of its absolute insolubility in water, serves as a stabilizing component of cell membranes and as a precursor of the bile salts and steroid hormones. Precursors of cholesterol are converted to ubiquinone, dolichol, and, in the skin, to cholecalciferol, the active form of vitamin D. As a major component of blood lipoproteins, cholesterol can appear in its free, unesterifiedform in the outer shell of these macromolecules and as cholesterol esters in the lipoprotein core. 

Recognize molecules where resonance structures are needed to describe the bonding. (Section 8.6)... 

All possible contacts have been taken into account, and flie normalized Boltzmann probability distributions, as well as the Shannon information entropies, have been calculated for each pair of the molecules (i.e., AE, BE, CE, DE) as functions of temperature T within flie range from 100 K to 400 K. The results (Fig. 15.9) show that flie molecule A (wifli flie simplest structure) does not recognize molecule E at any temperature T under study. The ignorance (Shannon s entropy) of A with respect to E is of the order of 5 bits. Transforming molecule A into B improves the... 

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