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Recognition Bioassays, Biosensors, DNA-Arrays and Pyrosequencing

MOLECULAR RECOGNITION BIOASSAYS, BIOSENSORS, DNA-ARRAYS AND PYROSEQUENCING [Pg.109]

The underlying principle of the analytical methods described in this chapter is that of biomolecular recognition the ability of a biomolecule to interact with one other particular type of biomolecule, like a key fitting a lock. With this key-lock principle, it is possible to specifically detect the target molecule, which could be an antigen, an antibody, a hormone, a DNA fragment or a sugar, even in very complex sample mixtures like urine or untreated blood. [Pg.109]

In bioassays, the molecular recognition between antibody and antigen as well as the signal generation for detection usually occur in solution or on an inert solid phase, whereas in biosensors, they are closely integrated on the surface of an active electronic device. DNA-arrays make use of the specific recognition of single strands of DNA, which only combine to form a double strand where [Pg.109]

The general principles of these techniques will be shown in the following sections and manifested by examples. [Pg.110]




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DNA arrays

DNA biosensors and bioassays

DNA recognition

Pyrosequencing

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