Receptor concept

Dmg receptors are chemical entities which are typically, but not exclusively, small molecules that interact with cellular components, frequently at the plasma membrane level (1,2). There are many types of receptors heat, light, immune, hormone, ion channel, toxin, and vims are but a few that can excite a cell. The receptor concept can be appHed generally to signal recognition processes where a chemical or physical signal is recognized. This recognition is translated into response (Fig. 3) and the process can be seen as a flow of information. 

Today, it is accepted that Langley and Ehrlich deserve comparable recognition for the introduction of the receptor concept. In the same years, biochemists studying the relationship between substrate concentration and enzyme velocity had also come to think that enzyme molecules must possess an active site that discriminates among various substrates and inhibitors. As often happens, different strands of evidence had converged to point to a single conclusion. 

Limbird LE (2004) The receptor concept a continuing evolution. Mol Intervent 4(6) 326-336 National Institute on Drug Abuse (1987) The second triennial report to Congress From the Secretary, Department of Health and Human Services. National Institute on Drug Abuse, Rockville, MD... 

The receptor concept has important practical consequences for the development of drugs and for arriving at therapeutic decisions in clinical practice. These consequences form the basis for understanding the actions and clinical uses of drugs described in almost every chapter of this book. They may be briefly summarized as follows ... 

Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A et al. (2007) Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A 104 359-64... 

As Bourne and von Zastrow (2004) noted, the receptor concept has important practical consequences for the development of new drugs ... 

Ehrlich studied first antimiobial agent, salvarsan, Ksulting fnm systematic synthesis efforts gave rise to receptor concept and chemotherapy concept... 

Ockner, R.K., Welslger, R.A., Gollan, J.L. Hepatic uptake of albumin bound substances albumin receptor concept. Amer. J. Physiol. 1983 245 413-418... 

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