Receptor cyclic order

Information may be stored in the architecture of the receptor, in its binding sites and in the ligand layer surrounding bound <7 it is read out at the rate of formation and dissociation of the supermolecule. In addition to size and shape, a receptor is characterized by the dimensionality, the connectivity and the cyclic order of its structural graph these features have been used to define a ligand structural index L ... 

R. Metivier, G. Penot, M. R. Hubner, G. Reid, H. Brand, M. Kos, and F. Gannon, Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751-763 (2003). 

Ferrocene appended 2,5-diamidopyrole receptors were subsequently developed in order to produce electrochemical sensors for anions (.Figure 7).8 The anion complexation of these compounds was reported through the results of both H NMR titration and cyclic voltammetry techniques. 

It has in fact been convincingly demonstrated that the anterior pituitary dopamine receptor is negatively coupled to adenylate cyclase in both tumoral (26), and normal (54) adenohypophysial tissue. Thus, the adenohypophysis cannot be taken, as originally proposed (36), as example of a receptor not coupled to adenylate cyclase. Moreover, it is well known that some dopaminergic responses appear independent of cyclic AMP (74, 75, 76). In order to take into account all the available data, it appears preferable to use the terminology DA+, DA and DA. (54, Fig. 4). Other advantages of this terminology are its clear separation from the nomen-... 

In order to support the contention that the protonated forms of sapphyrin have a role to play as anion receptors, particularly for physiologically important species such as phosphates and carboxylates, efforts were made to crystallize complexes containing these anions. In the case of phosphate, a number of such structures have in fact been obtained. Two are considered particularly informative. The first involves the 1 1 complex formed between monobasic phosphoric acid and diprotonated sapphyrin 10.6 (Figure 10.5.15) and the second, the mixed salt of diprotonated sapphyrin 10.29, chloride anion, and cyclic-AMP (Figure 10.5.16). ... 

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