Recent Updates on Improvement Strategies for Polyhydroxyalkanoates Production

3 Recent Updates on Improvement Strategies for Polyhydroxyalkanoates Production 

Zakaria and co-workers [28] reported the use of Comamonas sp. FBI 72 for the fed-batch production of copolymer poly(3HB-co-3HV) using a mixed organic acids treated palm oil mill effluent (POME) in a 2 1 bioreactor. A PHA content of 59 wt% and 3HV monomer composition of 21 mol% was obtained when the two-stage cultivation method was used. This method involves growing cells in a nutrient-rich medium for about 12 h, followed by inoculation of the production medium and supply of concentrated organic acids from treated POME using the fed-batch strategy. 

Gobi and Vadivelu [29] recently reported aerobic dynamic feeding as a strategy for the accumnlation of PHA. This is the first report 

The isolation of thermophilic bacteria capable of producing PHA was discovered by Xu and co-workers [32], The PHB-accumulating bacterium Chelatococcus daeguensis TADl was isolated from the biofilm of a biotrickling filter, used for the removal of nitrogen oxides it was found that PHB production was growth associated and PHB 

The use of mixed microbial cultures and optimisation strategies in fermentations can be a viable strategy to obtain a high cell density for the improvement of PHA production at an industrial level. Therefore, further studies should be initiated in order to obtain higher productivity of PHA with an associated lower cost of production. 

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