Reagent mixture synthesis

Reagent Mixture Synthesis towards Combinatorial Libraries... 

In the literature, few examples exist for combinatorial synthesis in solution [68], with most being one- or two-step parallel synthesis of individual compounds or reagent-mixture synthesis of compound mixtures. Pools of dimeric compounds including esters, amides and carbamates have been successfully prepared without needing further purification. One example of a reaction which is particularly applicable to combinatorial synthesis in solution is a multicomponent reaction, such as the Ugi four-component reaction, as it can produce four points of diversity in a single step [69-71],... 

Reagent Mixture Synthesis Towards Combinatorial Libraries 10... 

As a chemical compound, methane is not very reactive. It does not react with acids or bases under normal conditions. It reacts, however, with a limited number of reagents such as oxygen and chlorine under specific conditions. For example, it is partially oxidized with a limited amount of oxygen to a carbon monoxide-hydrogen mixture at high temperatures in presence of a catalyst. The mixture (synthesis gas) is an important building block for many chemicals. (Chapter 5). 

The Oxidation of Some Carbohydrate Derivatives using Acetic Anhydride - Methyl Sulphoxide Mixtures and the Pfitzner-Moffat Reagent. Facile Synthesis of 3-Acetamido-3-deoxy-D-glucose and 3-Amino-3-deoxy-D-xylose, J. S. Brimacombe, J. G. H. Bryan, A. Husain, M. Stacey, and M. S. 

Fig. 32 Fluorous mixture synthesis of fused-tricyclic hydantoins. Reagents and conditions a Mo(CO)6, DMSO, toluene, MW 150 °C, 35 min, closed system b TFA CH2CI2 (1 1), rt c PhC2H4NH2, PyBOP, i-Pr2EtN, MeOH, CH2CI2 followed by flash chromatography and F-HPLC d i-Pr2EtN, MeOH, MW 140 °C, 40 min, followed by F-SPE...

Compounds 68 have been obtained by one-pot cyclization of acyclic tetraamine 122 with ct-dicarbonyl reagents. This synthesis is not stereoselective, providing a mixture of vicinal isomers cis/trans of the bis-aminal 68 (Equation 11) <1998TL6861, 2003EJ01050, 2003T4573, 2005JOC7042>. 

Exercise 13-16 Devise a synthesis of 2-chloro-2,4,4-trimethylpentane from organic compounds with four carbons or less and any necessary inorganic reagents. Your synthesis should involve the C-C bond-forming reactions listed in Table 13-4 and other reactions shown in Table 13-5. The product should be 2-chloro-2,4,4-trimethyl-pentane and not a mixture of its isomers. 

Employing the teabag approach for parallel synthesis, the reagent mixture method, and the libraries from libraries concept, a wide range of different small molecule compounds was successfully prepared in our laboratory during the past decade. Starting from amino acids and short... 

The corresponding reagents prepared from primary amines and phosphorus pentoxide were not easy to handle. Instead, a reagent mixture which was prepared from phosphorus pentoxide, primary amine hydrochloride, and N,N-dimethylcyclohexylamine was useful at 250 °C for the synthesis of N-substituted 2-aminoquinolines from the corresponding oxo compound [ 7 ]. ... 

The word library is used to define a collection of compounds usually built around a common structural motif. There are three general approaches to library preparation parallel synthesis, mixture synthesis and split synthesis. One of these preferred strategies, parallel synthesis, is the approach where the compounds are made individually by automated or semi-automated methods. The library members may be made either in solution by classical methods, in solution attached to a polymeric carrier or on solid support. In parallel synthesis there must be linkage to a spatially defined position. The structure of the product is inferred from the position of the reactor and by the order of addition of the synthons and reagents at that position in space. Every possible member, resulting from the combinatorial mix of the synthons, need not be included in the library. 

Brimacombe, J S, Bryan, J G H, Husain, A, Stacey, M, Tolley, M S, The oxidation of some carbohydrate derivatives, using acid anhydride-methyl sulphoxide mixtures and the Pfitzner-Moffatt reagent. Facile synthesis of 3-acetamido-3-deoxy-D-glucose and 3-amino-3-deoxy-D-xylose,... 

Allylic 1,4-diols also deoxygenate to give conjugated dienes using a Ti° catalyst prepared from TiCU and LAH or TiCb and LAH. The latter reagent mixture has been exploited in a synthesis of vitamin A (53 equation 13). ... 

In the so-called reagent mixture synthetic approach towards combinatorial libraries of compound mixtures, each reaction step of the combinatorial synthesis is carried out with... 

Figure 2 (a) The divide, couple, and recombine method of library synthesis, (b) The reagent mixture approach. 

---