Reactive hypoglycaemia

Vilsboll T, Krarup T, Madsbad S, Holst JJ. No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose. Diabet Med 2001 18(2) 144-9. 

El-Ouaghhdi A, Rehring E, Schweizer A, Holmes D, Nauck MA. The dipeptidyl peptidase IV inhibitor LAF237 does not accentuate reactive hypoglycaemia caused by the sulfonylurea ghbenclamide administered before an oral glucose load in healthy subjects (abstract 507-P). Diabetes 2003 52(Suppl. 1) A 118. 

Reactive hypoglycaemia. This is when hypoglycaemia results from the ingestion of a particular substance, e.g. 

The combined effect of p-CyD with absorption enhancers such as sodium glycocholate or Azone on the nasal absorption of human fibroblast interferon-p in powder form in rabbits has been described. HP-p-CyD was useful as a biocompatible solubilizer for lipophilic absorption enhancers involved in the nasal preparations of peptides. When insulin was administered nasally to rats, simultaneous use of an oily penetration enhancer, HPE-101, (l-[2-(decylthio)-ethyl]azacyclopentane-2-one) or oleic acid solubilized in HP-P-CyD showed a marked increase in serum immuno-reactive insulin levels and marked hypoglycaemia (Fig. 38.10). The potentiation of the enhancing effect of HPE-101 by HP-P-CyD can be explained by the facilitated transfer of HPE-101 into the nasal mucosa. Studies on the release of membrane proteins and scanning electron-microscopic observations of rat nasal mucosa indicated that the local mucosal damage due to the combination with HP-P-CyD may not be serious obstacles to their safe use. 

Several workers have noted that rats sometimes failed to respond with a characteristic anaphylactoid oedema when injected with egg-white [171, 248, 401, 402, 447] or dextran [263, 344, 345, 361, 411, 464, 605] however, it was Harris and West [275] who first differentiated between rats which occasionally failed to show an oedema response and those animals which never responded. These workers found that out of 832 Wistar albino rats injected systemically with egg-white or dextran, no fewer than 162 failed to show the characteristic symptoms of the anaphylactoid reaction. Moreover, procedures such as adrenalectomy or hypoglycaemia which were known to potentiate the reaction failed to facilitate the response in the resistant animals. Despite subsequent research effort no physiological, biochemical or immunological difference between these 2 types of rat has yet been isolated which will explain this lack of reactivity to egg-white and dextran. 

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