Reaction with 2-nitropropane-1,3-diol

Polyfunctional fluoronitro alcohois are provided by tlie SRNl reaction of a perfluoroalkyl iodide or alkylene diiodides with the anhydrous lithium salt of 2-nitropropane l,3-diol acetonide. Hydrolysis of the resulting perfluoroalkyl-... 

Reaction of 1-nitropropane with glutaraldehyde in aqueous ethanol in the presence of sodium hydroxide yields a mixture of two products, the major component of which, lr-ethyl-l-nitrocyclohexane-2c,6f-diol (98), can be isolated in 36% yield ). Acid-catalyzed acetylation converts (98) into the di-O-acetate, hydrogenation yields the corresponding amine, which has been characterized as the hydroacetate, N-acetate and triacetate. Configurational assignments followed from NMR data, which clearly showed the steric non-equivalence of the two hydroxyl groups vicinal to the tertiary center. 

The reaction of 1-nitropropane, formaldehyde, and ethylene-diamine gave 151 together with a small amount of 152.156 Compound 151 was also prepared by reaction of 152 with 2-nitro-2-ethylpropane-1,3-diol in the presence of base.155,156... 

Other substances to be considered are those not added intentionally, but formed by the reaction between different ingredients whether during manufacture or storage, as is the case of nitrosamines. These hazardous substances can be formed by reaction of amines with nitrosat-ing agents (such as sodium nitrite or preservatives like 2-bromo-2-nitropropane-l,3-diol,... 

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