Reaction of Lithiomethyl Isocyanide with Hexyl Bromide, Oxirane and Cyclohexanone

6 Reaction of Lithiomethyl Isocyanide with Hexyl Bromide, Oxirane, and Cyclohexanone (Note 1) 

In order to avoid complaints about the stench, all operations with isonitriles should be carried out in a well-ventilated hood. The glassware used for the syntheses can be cleaned with a mixture of acetone and dilute (4N) hydrochloric acid. 

If the temperature is allowed to rise too fast, the reaction mixture turns brown, due to (unknown) side-reactions, and yields of the products are considerably lower. 

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