REACCS Molecular Design Limited

The major commercially available reaction indexing programs are REACCS (Molecular Design Limited), SYNLIB (started by Clark Still, developed by Smith, Kline and French and now sold by Dan Chodosh), ORAC (developed at the University of Leeds) and DARC-RMS (Telelsystemes). Pfizer s in-house system CONTRAST is noteworthy but is not available outside Pfizer. The release of CASREACT by Chemical Abstracts is awaited with interest. 

ChemTalk terminal emulation to run Molecular Design Limited s reaction indexing software REACCS on a mini/mainframe computer for access to centralized structure-based synthetic information ... 

REACCS - Reaction indexing system for in-house use, hardware supported, DEC VAX, IBM mainframe, Prime, available from Molecular Design Limited, 2132 Farallon Drive, San Leandro, CA 94577, U.S.A. 

REACCS, the reaction management system developed by Molecular Design Limited, effectively handles information on reactions as well as on molecules. The use of this program in environments as different as laboratories in basic research or process... 

Once the starting point of the synthesis is established using CHIRON then another program, REACCS, from Molecular Design Limited (MDL), can be used to fill in the details of the synthetic pathway that leads to the chiral product. 

The final chapters cover other aspects of chemical reaction handUng. Josef Brandt of the Technical University of Munich describes a tool for coding cychsation reactions Dan Meyer of ART Inc, and his co-workers, have studied chemical reaction retrieval using citation-based relationships Glen Hopkinson and others at ORAC write about reaction sequence searching and Brad Christie and Tom Moock of Molecular Design Limited discuss multistep reaction schemes in REACCS. 

Figure 14 Number of publications per year in the CJACS file mentioning MACCS, REACCS, ISIS, or MDL. The word isis has multiple meaning, including the name of a pharmaceutical company hence the search was narrowed as appropriate. The search queries for each curve were (1) maces, (2) reaccs, (3) mdl or molecular(w)de-sign(w)ltd or molecular(w)design(w)limited, and (4) isis and (mdl or molecu-lar(w)design).

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