Myths 88-10-2 ratios

To address this myth, we need to digress briefly to explain some of the more common types of assays used in HTS. A number of different types of readout can be used. Simple absorption measurements can be done, but given the short path lengths afforded by miniature wells and keeping Beer s Law in mind, it s obvious that it can often be a challenge to get a good signal-to-noise ratio here. All the same, this simplest of all techniques does find an occasional use. ... 

The most dangerous combination in design of the compression section is a large compression ratio and a short compression section length. This will lead very easily to plugging. Rapid compression screws should be avoided for this very reason. One of the myths in screw design is that certain polymers, e.g., nylon, require a very... 

The data collection and analytical methods used by Heinrich to develop the 88-10-2 ratios are unsupportable. Heinrich s premise that unsafe acts are the primary causes of occupational accidents cannot be sustained. The myth represented by those ratios must be dislodged from the practice of safety and actively refuted by safety professionals. 

One of the more persistent urban myths of forensic science is the belief that the human body can somehow erupt into flame and rapidly burn down to ashes with no discernible ignition source and nearly no peripheral burning. The material discussed in Chapter 9 concerning heat and mass transfer, fuel-air ratios, flammability limits, and the conditions that must be met for successful ignition are sufficient to debunk any ideas of spontaneous human combustion, but the myth persists. 

I could not end this brief list of unfounded claims wifhouf adding the most popular myth in the field of industrial safety. This ratio between at-risk behavior and injury was first proposed in the 1930s by H. W. Heinrich (1931). It has been repeated so often, some safety pros refer to it as "Heinrich s Law." It started as a mere estimate, and after years of use in srfety speeches and publications, without any empirical verification, its status was elevated to "basic principle" or "natural law."... 

P. Bourdoux, F. Delange, S. Filetti, C. Thilly and AM Ermans. Reliability of the lodine/creatinine ratio a myth In Thyroid Disorders associated with Iodine Deficiency and Excess, R. Hall and J. Kobberling, eds. Raven Press, 22, New-York 145 (1985). 

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