Rational Design of New Catalysts on Enzyme and Protein Basis

Rational Design of New Catalysts on Enzyme and Protein Basis 

One of the most direct questions to ask in the perspective of enzyme design is whether an already existing protein with a binding pocket might be turned into a new catalyst by introducing catalytic residues directly, rather than by the elaborated TSA mimicry approach used for catalytic antibodies, hoping to create a new biocatalyst that could harness both the activity and the selectivity, in particular stereoselectivity, that is possible with enzymes. 

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