Rashes suramin

Suramin is administered after a 200-mg intravenous test dose. Regimens that have been used include 1 g on days 1, 3, 7, 14, and 21 or 1 g each week for 5 weeks. Combination therapy with pentamidine may improve efficacy. Suramin can also be used for chemoprophylaxis against African trypanosomiasis. Adverse effects are common. Immediate reactions can include fatigue, nausea, vomiting, and, more rarely, seizures, shock, and death. Later reactions include fever, rash, headache, paresthesias, neuropathies, renal abnormalities including proteinuria, chronic diarrhea, hemolytic anemia, and agranulocytosis. 

Frequent adverse effects of suramin were rash, chills, fever, and taste disturbance. In contrast to the results of earlier studies, in which different suramin dosage regimens were used, neurological, renal, hepatic, and coagulation abnormahties were rare. 

Muscle pain and joint stiffness nausea transaminase elevations T-wave flattening or inversion weakness colic liver damage bradycardia leukopenia diarrhea rash pruritus myocardial damage hemolytic anemia renal damage shock sudden death Suramin Sodium... 

D. Suramin This polyanionic compound is a drug of choice for the early hemolymphatic stages of African trypanosomiasis (before CNS involvement). It is also an alternative to ivermectin in the treatment of onchocerciasis (see Chapter 54). Suramin is used parenterally and causes skin rashes, gastrointestinal distress, and neurologic complications. 

Suramin is the drug of choice for the early hemolymphatic stage of both Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense infections before nervous system invasion occurs [17 ]. The dose is 15-20 mg/kg/week, given intravenously, up to a maximum single dose of 1 g. Suramin, which is excreted by the kidneys, binds to plasma proteins and can persist in the circulation in low concentrations for as long as 3 months. A single course for an adult is usually 5 g, never to exceed 7 g. The primary adverse reactions are fever, rash, conjunctivitis, renal insufficiency, abdominal pain, paresthesia, and muscle pain. 

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