Rapid tooling

Gouldson, C., Rapid Tooling Processes and Selection Criteria, SPE-ANTEC1996. 

Grimm, T., Rapid Tooling is not the Future, It is Today, MoldMaking Tech., Feb. 2000. 

The advent of more accurate and rapid tools in chemoin-formatics and virtual screening makes it possible to design and synthesize a small subset of representative compounds (focused library) of a larger library. Out of various improved methods these two diversity- or structure-based approaches are frequently exercised in the design of a focused library. Once the 3D coordinates of a protein target are determined by either X-ray crystal structures or NMR, a structure-based library design is a more productive and viable approach. 

Similar work is being performed by Folke Lind of Sweden [92], He is introducing equipment to monitor tissue oxygenation of patients in need of hyperbaric oxygen (HBO) treatment. Tissue perfusion and oxygenation are objective parameters that support the decision to administer HBO and help determine the necessary number of treatments. Since hypoxia is reversible, NIR is believed to be the most rapid tool for saving life and limb in a trauma situation. 

Rocha, S.M., Coutinho, P., Barros, A., Delgadillo, I., and Coimbra, M.A. (2006). Rapid tool for distinction of wines based on the global volatile signature, / Chromatogr. A, 1114,188-197. 

In conclusion, PAH and soil evolution indexes are simple and rapid tools for the characterisation of PAH-contaminated soils in terms of level and repartition of pollution and for the prediction of their potential biotreatability. From an environmental point of view, they permit pointing out sensitive zones and defining priorities in terms of decontamination. 

Inducing an electromagnetic field eliminates the need for an electrode array and, therefore, the electromagnetic field method is a more rapid tool for surveying. The elimination of electrodes to measure electrical properties of subsurface materials also enables electromagnetic surveys to be conducted in many areas where resistivity surveys cannot be considered (i.e. pavement areas, very dry sandy soils, frozen ground, railroad tracks, etc.). Electromagnetic conductivity surveys may also be used to produce rapid continuous profiles up to depths of 15 meters. 

Aluminum and magnesium alloys are commonly friction stir welded with ambient aircooled tools and anvils. Coolant cooling of the tool is not required with aluminum, and magnesium alloys, but the coolant does provide an equilibrium tool temperature for the entire tool usage, especially for long welds, and rapid tool changes are easily performed. Midling and... 

The metabolic clearance of NCEs is most often studied with a combination of in vitro and in vivo approaches. There are several in vivo approaches that can be used to study metabolism in preclinical species and these along with in vitro results can often shed mechanistic insight into the problems associated with rapid metabolic clearance and incomplete oral bioavailability due to first-pass metabolism. Modern LC-MS/MS measurement of plasma drug eoncentrations provide a rapid tool to assess oral bioavailabihty of new eandidate compounds and allows for early definition of bioavailability problems. When bioavailability... 

Rapid protot5rping technologies (RPT), 1288 Rapid setup, 547 Rapid tooling, 1288 Rate(s) of return before-tax, 2334... 

The competitiveness of materials is influenced to a considerable degree by how much time is required to produce prototypes rapid prototyping) and tooling techniques rapid tooling). The integration of rapid engineering with simultaneous engineering (CAD, CAE, CIM, TQM. ..) is now considered the state of the art. A further opportunity is presented by the continued intensive development of products suitable for inmold assembly techniques. 

Rapid prototyping (functional parts parallel to series production) and rapid tooling continue to gain ground. 

---