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Raltitrexed

CCifiH]yBrN203 112888-39-8) see Raltitrexed 2-(bromomethyl)-l,3-dioxolane-4-methanol... [Pg.2314]

C(,H,C102 18997-19-8) see Pivampicillin Pivmecillinam Raltitrexed l>chIoro-2-methyl-2-propanol... [Pg.2331]

C]7H24N20, 2378-95-2) see Methotrexate diethyl Ai-(5-methylamino-2-thenoyl)-L-glutamate (C15H22N2O5S 112889-02-8) see Raltitrexed diethyl (l-methylbutyl)malonate (C12H22O4 117-47-5) see Secobarbital diethyl methylmalonate... [Pg.2352]

An important factor in the resistance to chemotherapy drugs such as 5-fhiorour-acil and Raltitrexed is an increase in TS expression [72, 37]. The TS enhancer region polymorphism may be one mechanism responsible for increasing TS gene expression. [Pg.503]

Raltitrexed is a folic acid analogue which inhibits thymidylate synthetase. Intracellularly formed raltitrexed polyglutamates are even stronger inhibitors of thymidylate synthetase than the parent compound. Similar to methotrexate polyglutamates... [Pg.452]

Folic acid analogs methotrexate sodium raltitrexed disodium... [Pg.619]

Nozoe Y, Ogata Y, Araki Y et al. Up-regulation in dihydropyrimidine dehydrogenase aetivity by raltitrexed causes antagonism in eombination with 5-fluorouraeil. Anticancer Res 2003 23 4663 669. [Pg.261]

Salgado J, Zabalegui N, Gil C et al. Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer. Oncol Pep 2007 17 325-328. [Pg.264]

Fleck C, Hilger R, Jurkutat S, et al. Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma. Urol Res 2002 30 256-262. [Pg.181]

Raltitrexed <1998MI423> can be used in the treatment of advanced colorectal cancer. Substituted 2-thienyl-1,8-naphthyridin-4-ones 25 < 1999JME4081 > exhibit cyctotoxicity and inhibit tubulin polymerization. Cyclopentathiophenes, for example, 26-29 <2002BMC2185>, have been successfully used against leukemia cell lines. [Pg.937]

FOLINATE RALTITREXED Theoretical risk of 1 efficacy of raltitrexed Folinate antagonizes the anti-DNA effect of raltitrexed Be aware watch for poor response to raltitrexed... [Pg.307]

See other pages where Raltitrexed is mentioned: [Pg.1783]    [Pg.1783]    [Pg.2316]    [Pg.2354]    [Pg.2354]    [Pg.2367]    [Pg.2405]    [Pg.502]    [Pg.518]    [Pg.596]    [Pg.605]    [Pg.597]    [Pg.607]    [Pg.66]    [Pg.66]    [Pg.266]    [Pg.452]    [Pg.247]    [Pg.278]    [Pg.279]    [Pg.551]    [Pg.1783]    [Pg.1783]    [Pg.2314]    [Pg.2316]    [Pg.2405]    [Pg.298]    [Pg.298]    [Pg.937]    [Pg.338]    [Pg.338]    [Pg.842]    [Pg.5457]    [Pg.267]   
See also in sourсe #XX -- [ Pg.66 ]

See also in sourсe #XX -- [ Pg.447 ]

See also in sourсe #XX -- [ Pg.1783 ]

See also in sourсe #XX -- [ Pg.431 ]



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Folic acid Raltitrexed

Raltitrexed Folinates

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