Folic acid analogs

An electron impact mass spectrum of calcium leuco-vorin has not been obtained because the compound is not sufficiently volatile. It would be difficult to isolate the free acid without first dehydrating the compound. Due to its ionic nature, calcium leucovorin will not dissolve in common silylating reagents. Field desorption, another mass spectral technique, generally lends itself more to compounds like leucovorin. Indeed, this technique has been applied successfully to methotrexate and other folic acid analogs.1 ... 

A. Cheung, L. Pont, and P. Lim, Applications of high speed liquid chromatography to some folic acid analogs. In Nucleic Acid Chemistry Improved and New Synthetic Procedures, Methods and Techniques, Part Two, (eds. 

Antimetabolites. This class of drugs includes purine, pyrimidine, and folic acid analogs that have been successfully used to treat various carcinomas, autoimmune diseases, and dermatological disorders such as psoriasis. Because of their structural similarities to normal components of DNA and RNA synthesis, they are capable of competing with the normal macromolecules and alkylating biological nucleophiles. 

Methotrexate Folic acid analog cancer chemotherapy, arthritis Inhibits proliferation T-cell suppression granulocytopenia lymphocytopenia... 

Folic acid analogs methotrexate sodium raltitrexed disodium... 

Thymidylate synthase requires methylene tetrahydro-folate as a reductant and the reduction of dihydrofolate is also an important part of the process. In protozoa dihydrofolate reductase and thymidylate synthase occur as a singlechain bifunctional enzyme.f As has been pointed out in the main text, such folic acid analogs as methotrexate are among the most useful anticancer drugs. By inhibiting dihydrofolate reductase they deprive thymidylate synthase of an essential substrate. 

Methotrexate is a folic acid analog. It inhibits folic acid synthetic pathways and DNA synthesis (Bannwarth et al., 1994). Methotrexate is widely used in the treatment of breast and other cancers. Methotrexate has recently gained favor for, and is approved for, the treatment of rheumatoid arthritis in adults who have severe active classical rheumatoid arthritis (O Dell, 2004). It is also used to treat psoriasis and graft vs host disease. 

Methotrexate (MTX, amethopterin) is a folic acid analog used to inhibit Dihydrofolate Reductase. 

Platinum coordination complexes Antimetabolites Folic acid analogs... 

The folic acid analog trimetrexate is a competitive inhibitor of bacterial and protozoan dihydrofolate reductase. This compound is currently used as a treatment for Pneumocystis carinii pneumonia (PCP) in patients with immunocompromising conditions. 

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