Radiotherapy interaction

Keywords Antibacterial activity, anticancer activity, antioxidant properties, antiviral activity, cell protection, contrast agent, drag delivery, photodynamic therapy, protein interaction, radiotherapy, toxicity... 

Selective COX-2 inhibitors are currently being investigated in cancer patients in phase I and early phase II clinical trials. The currently available data would suggest that specific inhibitors of COX-2 have the potential to increase the therapeutic ratio of radiotherapy in tumors that express COX-2, and that clinical investigation of this interaction is warranted. 

There is a potentially dangerous interaction with cancer treatment in patients with schizophrenia taking clozapine, because of the unpredictable risk of myelotoxicity. However, a 37-year-old patient taking clozapine for schizophrenia was given full-dose cisplatin and concomitant radiotherapy for an undifferentiated nasopharyngeal carcinoma, without significant neutropenia (250). 

The biodistribution and radiotherapy data, together with required data for Lu-DOTATATE and the tumour size, were incorporated into a response model based on the linear quadratic model. This model provides data on interactions among important radiobiological parameters. 

Apetoh L et al. The interaction between HMGBl and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev 2007 220 47-59. 

One of the varieties of malignant tumor radiotherapy is neutron capture therapy (NCT) (De Stasio et al., 2001). NCT is a cancer therapy that uses radiation from the reaction of capturing thermal neutrons by or Gd isotopes, previously accumulated in tumor cells (Detta and Craickshank, 2009 Turanska et al., 2010). The result of thermal neutron interaction with isotopes is a significant cytotoxic effect caused by the influence of the products of nuclear reaction on cancer cells. 

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