Radiology, advances

N. Marmiroli et al (eds.), Advanced Science and Technology for Biological Decontamination of Sites Affected by Chemical and Radiological Nuclear Agents, 03—14. 2007 Springer. 

Landry JC, Harris W Yang GY, et al. Neoadjuvant treatment with GEM, cisplatin, 5-FU and accelerated hyperfractionated radiation therapy in advanced GI malignancy. Radiology 2000 217 147. 

In a phase I dose escalation study in locally advanced HNC patients, a concomitant regimen of weekly docetaxel and irinotecan and conventional radiotherapy was combined (47). Docetaxel was given over 20 min on d 1, irinotecan was administered as 30 min infusion on d 3. Three docetaxel/irinotecan dose levels were compared 20/25 mg/m2 (level 1), 20/40 mg/m2 (dose level 2), and 25/55 mg/m2 (dose level 3). Severe asthenia resulted in all patients at dose level 3. Myelosuppression was minimal. Complete responses were seen radiologically in 75% of patients and a partial response in 25% of patients. 

During World War II, a different exposure situation was created in the United States by the Manhattan Project. Several hundreds of thousands of workers were recruited to a new industry in remote and secret locations. Since some of the hazards of working with radiation were recognized in advance, workers at many sites were monitored for radiation exposure. A new discipline. Health Physics, was created to provide radiological protection. The systematic collection of dosimetry records created an opportunity to investigate relationships between repeated exposure to small doses of radiation and disease. 

Santell, J. P., Hicks, R. W., and Cousins, D. D. (2005), MEDMARXData Report A Chart-book of 2000-2004 Findings from Intensive Care Units and Radiological Services, USP Center for Advancement of Patient Safety, Rockville, MD. 

Davis SD, Berkmen YM, Wang JC. Interleukin-2 therapy for advanced renal cell carcinoma radiographic evaluation of response and complications. Radiology 1990 177(1) 127-31. 

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