Hyperfractionated accelerated radiation therapy

Other trials attempted to improve the results of sequential chemoradiation by using newer ChT agents and/or intensifying the RT component by the use of accelerated fractionation, based on the success of the British CHART regimen. A phase II trial of paclitaxel and carboplatin followed by hyperfractionated accelerated radiation therapy (HART) to... 

Budach V, Stuschke M, Budach W, et al (2005) Hyperfraction-ated accelerated chemoradiation with concurrent fluo-rouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer final results of the radiotherapy cooperative clinical trials group of the German Cancer Society 95-06 Prospective Randomized Trial. J Clin Oncol 23 1125-1135... 

The median follow-up was 23 mo for the 1073 evaluable patients. Patients that received hyperfractionated or accelerated radiation therapy with boost had increased locoregional control (p = 0.045 and p = 0.05, respectively) and a trend toward improved disease-free survival (DFS) (p = 0.067 and p = 0.054, respectively) in comparison to conventional radiation therapy. However, there was no improvement in overall survival(s). Patients given accelerated split-course fractionation had similar outcomes to those who had received conventional radiotherapy. Hyperfractionated radiation therapy is the method of choice for combined chemoradiotherapy in current investigative approaches for head and neck cancer. 

Landry JC, Harris W Yang GY, et al. Neoadjuvant treatment with GEM, cisplatin, 5-FU and accelerated hyperfractionated radiation therapy in advanced GI malignancy. Radiology 2000 217 147. 

Fu KK, Pajak TF, Trotti A, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas first report of RTOG 9003. lnt J Radiat Oncol Biol Phys 2000 48 7-16. 

Jeremic B, Shibamoto Y, Acimovic L, et al. Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer a randomized study. J Clin... 

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