Radio frequency encoding

In a similar approach, a pretuned glass encased microchip set to emit a unique binary code is placed in a polypropylene tea bag loaded with polystyrene beads. Using a modified split synthesis approach, a 125-membered tripeptide library N-capped as the /r-carboxy-cinnamic acid amide was prepared on Rink resin. Each porous reactor contained a radio frequency transporter which successfully defined the structure of two inhibitors of protein tyrosine phosphatase [37], 

Encoding techniques offer a powerful approach to rapidly dissecting out significant SAR information from an entire library. Among the methods available, the chemically 

10 Furka, A., Sebestyen, E, Asgedom, M. and Dibo, G., 14th International Congress ofBiochemistry, Vol. 5, Prague, Czechoslovakia, 10-15 July 1988, Walter de Gruyter, Berlin, Germany, 1989, p. 47 (abstract). 

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FIGURE 9.23 Radio frequency encoding basic principles. 

In 1997, Xiao et al. prepared the first C3 -N modified taxane library with 400 compounds by a radio-frequency encoded, solid-phase synthesis method. However, they did not report the biological assay data. Although combichem is a powerful tool in medicinal chemistry, only a few reports have appeared in this field to date, maybe because of the complexity in taxane structure and chemistry. 

Nicolaou, K.C. et al.. Radio frequency encoded combinatorial chemistry, Angew. Chem., Int. Ed. Engl., 34, 2289, 1995. 

Proximity Embedded radio frequency circuits encoded with unique information Long Virtually none Moderate-high... 

In this study, a nonchemical means of encoding the identity of each compound was used. The original polymer-bound reagent was placed in a porous microreactor equipped with a radio-frequency device that can be used for identification.168 The porous micro-... 

Moran, E. J. Sarshar, S. Cargill, J. F. Shahbaz, M. M. Lio, A. M. Mjalli, A. M. M. Armstrong, R. W. Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B, J. Am. Chem. Soc. 1995, 777,10787. 

For linear multistep syntheses, the split and recombine strategy is a fast and effective method ofproducing large libraries. In fact, a synthesis with x inputs andy chemical steps gives rise to a library of xy components. Chemical tagging methods have been used extensively for the identification of active components in such libraries [6]. An alternative to chemical tagging is a coding system that uses radio frequency (rf) encodable microchips. 

The discovery of chemical encoding technologies and radio-frequency (Rf) encoded synthesis have had a major impact on synthesis of lead discovery libraries. Both technolo-... 

A real combinatorial testing of libraries of small compound catalysts is hampered by the problem that the information about which catalyst reacted with the substrate to which product needs to be transferred. In the case of the highly inventive encoding techniques for libraries (e. g. via radio frequencies or bar codes), this problem may be solved in the future [23]. 

Moran, E. J., Sarshar, S., Cargill, J. F., et al. (1995) Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTPIB. J. Amer. Chem. Soc. 117, 10787-10788. 

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