Encoded radio-frequency tags

Moran, E. J. Sarshar, S. Cargill, J. F. Shahbaz, M. M. Lio, A. M. Mjalli, A. M. M. Armstrong, R. W. Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B, J. Am. Chem. Soc. 1995, 777,10787. 

Moran, E. J., Sarshar, S., Cargill, J. F., et al. (1995) Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTPIB. J. Amer. Chem. Soc. 117, 10787-10788. 

For linear multistep syntheses, the split and recombine strategy is a fast and effective method ofproducing large libraries. In fact, a synthesis with x inputs andy chemical steps gives rise to a library of xy components. Chemical tagging methods have been used extensively for the identification of active components in such libraries [6]. An alternative to chemical tagging is a coding system that uses radio frequency (rf) encodable microchips. 

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