Radiation-graft polymers

Scott, K., Taama, W. M. and Argyropoulos, R 2000. Performance of the direct methanol fuel cell with radiation-grafted polymer membranes. Journal of Membrane Science 171 119-130. 

Wang, H. and Capuano, G. A. 1998. Behavior of Raipore radiation-grafted polymer membranes in Hj/Oj fuel cells. Journal of the Electrochemical Society 145 780-784. 

SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES... 

Scheme 7 shows how trisaccharides were prepared on a radiation-grafted polymer surface.20 The photolabile 4-hydroxymethyl-3-nitrobenzamido handle21 and jV-iodosuccinimide-triethylsilyltriflate coupling chemistry were used. Product purities were similar to those obtained using Tentagel macrobeads. 

Expanding the variety and properties of linker groups increases the scope of practical applications of radiation-grafted polymer surfaces for the parallel synthesis of organic compounds. Linker molecules have a bearing on the types of reactions that can be performed and the ease of isolation of products after cleavage. 

Mimotopes has been involved in the development, use, and commercialization of radiation-grafted polymer surfaces for multiple parallel synthesis since the late 1980s.10-12 Although other workers have reported the use of radiation-graft polymers in solid-phase synthesis,13,14 as far as we are aware, the graft polymer devices manufactured and sold by Mimotopes (SynPhase Crowns, SynPhase Lanterns) are the only current commercial products of this type. These products are presented in Fig. 1. The SynPhase Lanterns are the current design for small molecule synthesis. The initial... 

Rager T. Structured radiation-grafted polymer films and membranes. J Appl Polym Sci... 

Hoffman, A.S. et ah. Immobilization of enzymes and antibodies to radiation grafted polymers for therapeutic and diagnostic applications, Radiat. Phys. Chem., 27, 265, 1986. 

Chen, J., M. Asano, T. Yamaki et al. 2006. Effect of crosslinkers on the preparation and properties of ETFE-based radiation-grafted polymer electrolyte membranes. Journal of Applied Polymer Science 100 4565-4574. 

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