Radiation genetic effect

Genetic Effect of Radiation—Inheritable change, chiefly mutations, produced by the absorption of ionizing radiation by germ cells. Genetic effects have not been observed in any human population exposed at any dose level. 

UNSCEAR. 1986. United Nations Scientific Committee on the Effects of Atomic Radiation. Genetic and somatic effects of ionizing radiation. New York United Nations. 

Radiation causes dominant lethal mutations in the medaka (Oryzias latipes) (Shima and Shimada 1991). Mosquitofish (Gambusia spp.) from radionuclide-contaminated ponds in South Carolina differed from conspecifics in reference ponds, as judged by the frequency of DNA markers, and this is consistent with the hypothesis that these DNA markers may originate from genetic elements that provide a selective advantage in contaminated habitats (Theodorakis et al. 1998). Ionizing radiation at low-level chronic exposure reportedly has no deleterious genetic effects on aquatic populations because exposure is compensated by density-dependent responses in fecundity (IAEA 1976). However, this needs verification. 

The Japanese atomic-bomb survivors also are a potentially important source of data on the dose-response relationship for severe hereditary responses. However, no evidence for inherited genetic effects has been observed in spite of nearly 50 y of study. In the absence of data in humans, estimates of the frequency of radiation-induced hereditary responses have been based primarily on data from studies in mice. 

The strategy adopted by this Committee, as well as by United Nations committees and other National Research Council committees in connection with radiation effects, is to concentrate on risk estimation for genetic effects that can be expected within the first half-dozen generations. 

National Council on Radiation Protection and Measurements. Genetic effects, pp. 22-64. In NCRP Report No. 64. Influence of Dose and Its Distribution in Time on... 

Genetic Effects of Radiation in Mice Developmental Effects of Radiation in Mice... 

W. L. Russel J. Shubert 60 ORNL, Biology Div. U. Pittsburgh, Graduate School of Public Health Principal Geneticist Genetics Genetic effects of radiation genetics of the house mouse... 

International symposium, Genetic Effects of Radiation and Radiomimetic Chemicals ... 

Crow, James F., and Seymour Abrahamson, 1965, Genetic effects of ionization radiation. In The Science of Ionizing Radiation, edited by Lewis E, Etter, 263-287. Springfield, 111. Charles C. Thomas,... 

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