Rabbit blood vessels

The P2X- ntagonism by PPADS has been confirmed in a wide range of tissues and cells including guinea-pig vas deferens [57], rabbit urinary bladder detrusor muscle [28], rabbit blood vessels [29], rat mesenteric arterial bed [30] (Table 3), rat isolated perfused kidney [58], rat sympathetic ganglia [59] and xenopus oocytes injected with RNA transcribed from a P2X cDNA clone from rat vas deferens [17]... 

Cheng, S. X Chen, Z. R and Chen, G. Q. Xhe expression of cross-linked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds. Biomater. 2008, 29(31), 4187- 194. 

Forstermann, U., Hertting, G., Neufang, B., 1984 The importance of endogenous prostaglandins other then prostacyclin for the mechanism of contractility of some rabbit blood vessels. Br. J. Pharmac. 81, 623-630. 

Pharmacological Action. According to Curci, oxyacanthine in doses of 01 to 0-2 gm. produces in rabbits quick and laboured respiration, muscular tremors, clonic convulsions and cessation of respiration before the heart stops. Raymond-Hamet states that oxyacanthine hydrochloride in a dose of 10 mgm. injected into the femoral artery of a dog produced dilation of the blood vessels in the leg and general hypotension. 

The controlled release from PTA-SA 50 50 of several drugs known to inhibit the formation of new blood vessels in vivo, cortisone and heparin, is shown in Fig. 9 (15). The inhibitors of angiogenesis delivered in vivo using this polyanhydride were shown to prevent new blood vessel growth for over 3 weeks, following the implantation of the VX2 carcinoma into rabbit cornea (15). 

FIGURE 9 Influence of angiogenesis inhibitors on blood vessel growth. Several inhibitors of angiogenesis were released from PTA-SA 50 50 in vivo. The effect of these agents on the growth of blood vessels around the VX2 carcinoma implanted into rabbit corneas was then determined as described in the text. 

In contrast, implantation of four small pieces of poly(N-palmitoyl-hydroxyproline ester) into four rabbit corneas elicited no pathological response in three corneas and a very mild inflammatory response in one cornea. Histological examination of the corneas 4 weeks postimplantation showed no invading blood vessels or migrating inflammatory cells in the area around the implants. 

The role of CuZnSOD on oxygen radical production in cerebral vessels has been studied. Didion et al. [28] demonstrated that endogenous CuZnSOD diminished superoxide levels in rabbit cerebral blood vessels and affected nitric oxide- and cyclooxygenase-mediated responses in cerebral microcirculation. A subsequent study by the same group [29] showed increased superoxide production and vascular dysfunction in CuZnSOD-deficient mice. Chang et al. [30] suggested that superoxide induced cytokines, which activated microglial... 

Fig. 10. Microdissection of a fresh rabbit fetus (day 29 of gestation) observation of the heart and the great blood vessels.

Prior to true subsurface bone spectroscopy, Penel and coworkers obtained bone Raman spectra using a titanium chamber with a fused silica window placed in the calvaria of New Zealand rabbits [2]. With this apparatus they were able to study both bone tissue and implanted hydroxyapatite and P-tricalcium phosphate over a 8-month period. In addition to bone spectra, hemoglobin spectra were obtained close to blood vessels. 

Fig. 8.18 Visualisation of the blood vessels of a rabbit with a dendritic Gadomer contrast agent (shown in red). The figure was kindly provided by Dr. H. Schmitt-Willich (Schering AG, Berlin)...

Hypotensive in cat, dog, and rabbit by direct CNS effect and blood vessel dilation 367... 

It has recently been claimed that the intravenous injection of hyalu-ronidase increases the permeability of the rabbit s blood vessels to protein, as measured by a decrease in plasma albumin and appearance of albumin in the liver and kidney.250 This effect is intensified by deoxycorticosterone, and inhibited by 1 g. of D-glucuronic acid. McCrea and Duran-Reynals251 have recently shown that the factor in hydrolyzed hyaluronic acid which apparently inactivates vaccinia virus is D-glucuronic acid. It may be that many of these phenomena are related to the inhibition of /3-D-glucuron-idase which can be produced by D-glucuronic acid.262... 

A comprehensive reivew of studies of the action of DA, agonists and antagonists in isolated blood vessels and organs was recently published (31). In general, there is good correlation between in vivo and in vitro data with isolated canine blood vessels. However, exceptions have been reported with isolated preparations of other species. The major differences are that sulpiride and its enantiomers appear to be much more potent in vivo than in vitro. Another discrepancy is that bromocriptine, which is inactive on DA, receptors in vivo, has been shown to cause DA-like vasodilation of the isolated perfused rat kidney and relaxation of rabbit mesenteric artery strips. 

For smaller species, proximal tubule segments can also be isolated from the entire kidney using in situ col-lagenase perfusion techniques (Tyson et al. 1990). Following anesthesia, the kidneys may be perfused via the aorta (mice) or renal arteries (rats, rabbits) for five minutes to remove the residual blood the kidneys and associated blood vessels are then removed and the perfusion continued for an additional 15-20 minutes with buffer containing 180 U/ml of Type I collagenase. The cortical tissue is then removed from the medulla and the tubules isolated as described above. The viability and function of tubules so isolated are comparable to those isolated without collagenase (Rodeheaver et al. 1990). 

Rabbits of either sex weighing 2.5 to 3.5 kg are used. A volume of 0.1 ml of the test solution is injected in the outer part of the rabbit s ear avoiding hitting any blood vessels. The same volume of saline is injected into the contralateral ear. A pale discoloration of the skin appears immediately, which disappears within 1 h in the control. 

Thrombin-Induced Rabbit Femoral Artery Thrombosis Localized thrombosis can also be produced in rabbit peripheral blood vessels such as the femoral artery by injection of thrombin, calcium chloride, and fresh blood via a side branch (Shebuski et al. 1988). 

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