Quisqualate receptor

Mayer, M. L. and Vyklicky, L., Jr. (1989) Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors. Proc. Natl. Acad. Sci. USA 86, 1411-1415. 

Tocco G., Shors T. J., Baudry M., and Thompson R. F. (1991). Selective increase of AMPA binding to the AMPA/quisqualate receptor in the hippocampus in response to acute stress. Brain Res. 559 168-171. 

AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a selective glutamate receptor agonist, which is selective for the AMPA subtype (previously called quisqualate receptors). It is bioisostere of glutamic add and an analogue of ibotenic acid. 

AMPA receptors (previously called quisqualate receptors) are permeant to NaVK- (and Ca in some heteromeric combinations) and are involved in fast excitatory synaptic transmission. They are activated by glutamate, and selectively by AMPA and (s)-5-fluorawillardine, and are used as pharmacological tools. 

Patneau DK, Mayer ML (1990) Structure-activity relationships for amino acid transmitter candidates acting at V-methyl-D-aspartate and quisqualate receptors. J Neurosci 70 2385-2399. 

Lester RAJ, Jahr CE (1990) Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons. Neuron 4 741-749. 

Ito I, Tanabe S, Kohda A et al (1990) Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J Physiol 424 533-543... 

Kano M, Kato K (1987) Quisqualate receptors are specifically involved in cerebellar synaptic plasticity. Nature, 325, 276-279. 

Felipo V, Minana MD, Cabedo H, et al. 1994. L-Camitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity. Neurochem Res 19(3) 373-377... 

Palmer, E., Monaghan, D.T. and Cotman, C.W. (1988). Glutamate receptors and phosphoinositide metabolism stimulation via quisqualate receptors is inhibited by A-methyl-D-aspartate receptor activation. Mol. Brain Res. 4 161-165. 

Wheat germ agglutinin enhances EPSCs in cultured postnatal rat hippocampal neurons by blocking ionotropic quisqualate receptor desensitization. J. Neurophysiol. 68 1930-1938. 

Thio, L.L., Clifford, D.B. and Zorumski, C.F. (1991). Characterization of quisqualate receptor desensitization in cultured postnatal rat hippocampal neurons. J. Neurosci. 11 3430-3441. 

McBain, C J, Boden, P., and Hill, R G. (1988) The kainate/quisqualate receptor CNQX, blocks the fast component of spontaneous epileptiform activity in organotypic culture of rat hippocampus. Neurosci Lett 93, 341—345. 

Quisqualic acid is an excitatory amino acid, like N-methyl-D-aspartic acid and kainic acid, and the receptor of this alkaloid is sometimes called the quisqualate receptor [4-6]. X-ray crystallography of quisqualic acid [7] was carried out, and a stereoselective total synthesis of this alkaloid [8] was achieved. 

Hoelscher, R Turski, L. Rreparation of benzo[f]quinoxalinediones as quisqualate receptor ligands. Ger. Offen. DE 4314592, 1994 Chem. Abstr. 1995,122, 187617. 

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