Codeine sulfate trihydrate

Codeine sulfate trihydrate Ammonium hydroxide Aluminum isopropoxide Potassium sodium tartrate tetrahydrate Palladium on carbon... 

Codeinone was prepared by oxidation of codeine sulfate trihydrate. A reaction mixture was prepared containing codeine sulfate trihydrate (10.4 g), deionized water (20 g) and isopropyl acetate (87.2 g) at ambient temperature. The reaction mixture was agitated and the resultant mixture cooled to about 20°C. Concentrated ammonium hydroxide (18.0 g) was added in several portions and the mixture was maintained at a temperature of about 20°C with stirring. Sting was continued for about 15 min, and then a small portion of the aqueous layer was withdrawn to check for pH value, which was to be advantageously maintained between 11.0 and 12.0. The aqueous layer was... 

Many drugs and excipients (cephalexin monohydrate, quinidine sulfate dihydrate, ampicillin trihydrate, codeine sulfate trihydrate, morphine sulfate dihydrate, dicalcium phosphate trihydrate, raffinose pentahy-drate, lactose monohydrate) utilize water as an integral part of their crystal structure. Solids that form specific crystal hydrates tend to sorb relatively small amounts of water to their external surface below a characteristic relative humidity, when initially dried to an anhydrous... 

---