Quantitative Comparisons of Mutagenic and Carcinogenic Activities

Initial work by Meselson and Russell has suggested that a fairly good correlation exists between the two potencies across a broad range of chemical classes. This initial study included only 14 chemicals, however, and it has been pointed out that the correlation between mutagenic and carcinogenic activities does not always hold within chemical classes such as the nitrosamines. It is clear that further work will be necessary to determine the extent of this type of correlation. Unfortunately, one of the principal difficulties in conducting this 

NONCARCINOGENIC CHRONIC EFFECTS TERATOGENIC/ REPRODUCTIVE EFFECTS AND NEUROTOXIC EFFECTS 

The following sections review some of the proposed testing guidelines relevant to these types of toxicities. 

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