Qualitative analysis cocaine

Stojanovska, N., Tahtouh, M., Kelly, T., Beavis, A., and Fu, S. 2014. Qualitative analysis of seized cocaine samples using desorption electrospray ionization—Mass spectrometry (DESI-MS), Drug Test. Anal., 7(5) 393-400. doi 10.1002/dta.l684. 

The combination of a pharmacodynamic model with a modem technique such as microdialysis is an attractive solution to assess pharmacokinetic/pharmacodyamic (PK/PD) relationships. Two separate stndies supported this idea. Esterom Solution is derived from the esterification of benzoylmethylecgonine (cocaine) and contains a mixture of components (McDonald and Lunte, 2003). This solution is intended to be a topical analgesic to relieve pain and increase the range of motion in patients with acute inflammation. A pharmacodynamic model can only provide information about the qualitative reduction in pain as a result of topical application of complete mixture. The dermal microdialysis analysis of tins mixture revealed that the only component that penetrated the skin was hydroxypropyl braizoylecgonine (McDonald and Lunte, 2003). Thus, the analgesic activity of the I Lstcrom Solution was caused by one component. 

Early chemical profiling attempted to establish batch links among illicit drug seizures by comparative studies, based on both qualitative and quantitative information, although success in achieving this has been varied. Such studies have been applied to link heroin and cocaine samples to common origins, based on the concentration of the organic impurities present. Isotopic analysis of impurities and intermediates has been employed in the comparison of seized heroin, methamphetamine, and ecstasy samples. X-ray diffraction and NMR spectroscopy (both and have been used to... 

Qualitative Thin-Layer Chromatography-Easy Ambient Sonic Spray Ionization Analysis of Seized Cocaine and Crack Cocaine... 292... 

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