Quadrapole mass spectrometer

Lawson, G. Todd, J.F.J. Radio-Frequency Quadrapole Mass Spectrometers. Chem. Brit. 1972,8,373-380. 

Dawson, P.H. Whetten, N.R. Nonlinear Resonances in Quadrapole Mass Spectrometers Due to Imperfect Fields. I. Quadrupole Ion Trap. Int. J. Mass Spectrom. Ion Phys. 1969, 2,45-59. 

Fig. 17.8. MS/MS schematic representation of MS/MS by quadrapole mass spectrometers. (A) Sample entry normally via ESI. (B) Precursor ion selection allowing only the ion of interest to continue through the mass spectrometer. (C) Collision-induced dissociation of the ion within a gas cell normally containing argon to produce fragments. (D) The products of fragmentation are focused and analysed via a ToF-mass analyser.

Gobey, J., Cole, M., Janiszewski, J., Covey, T., Chau, T., Kovarik, P., and Corr, J. (2005). Characterization and performance of MALDI on a triple quadrapole mass spectrometer for analysis and quantification of small molecules. Anal. Chem. 77 5643-5654. 

MS has long been used for the detection of low molecular weight gases. The devices are called residual gas analyzers and are typically magnetic sector or quadrapole instruments. The quadrapole mass spectrometer is usually the analyzer of choice... 

All nES/MS and nES/MS/MS measurements were made on a Perkin-Elmer Sciex API-in triple quadrapole mass spectrometer (Thornhill, Canada) equipped with the nanoelectrospray source designed by Matthias Wilm and Matthias Mann at the European Molecular Biology Laboratory, Germany (9). The long signal duration allowed the instrumental parameters to be optimi for each peptide interrogated by nES/MS/MS. Argon gas was used as the collision... 

Quadrapole mass analyzers are by far the most common type of mass spectrometer in use today and the literature on these type of analyzers is extensive. Quadrapole mass analyzers are often thought of as mass filters because they can be tuned to transmit ions of a narrow range of mass/charge (w/z) ratios. Fig. 6 shows a generalized block schematic of a quadrapole mass spectrometer. A typical quadrapole instrument separates ions with different masses by application of a combination of static and radio frequency electric fields to four cylindrical rods. A headspace gas sample is introduced at an inlet and fed into an ion source where electrons are emitted from a filament and ionize the sample gas. The sample ions are then accelerated in an electrical field and are injected into the opening at the center of the rods. In the simplest systems, one pair of rods is connected and attached to the positive... 

Fig. 6 Block schematic of a quadrapole mass spectrometer. (From Ref. ( p. 41. Copyright 2002 Advanstar Communications Inc.)...

The quadrapole mass spectrometer also employs an electron beam to ionize the particles using the quadrapole instead of a magnet to deflect the path of the particles and filter out all but the specific component to be analyzed. The quadrapole is a set of four similar and parallel rods (see Fig. 

QMS Quadrapole mass filter, quadrapole mass spectrometer... 

Liyu, Y. Amad, M.H. Winnik, W.M. Schoen, A.E. Schweingraber, H. Myl-chreest, I. Rudewicz, P.J. Investigation of an Enhanced Resolution Triple Quadrapole Mass Spectrometer for High-Throughput Liquid Chromatogra-phy/Tandem Mass Spectrometry Assays. Rapid Commun. Mass Spectrom. 2002, 16, 2060-2066. 

Hunt, D.F. Shabanowitz, J. Giordani, A.B. Collision Activated Decompositions in Mixture Analysis With a Triple Quadrapole Mass Spectrometer. Anal. Chem. 1980,52,386-390. 

Inglebert, R.L. Hennequin, J.F. Overall Transmission of Quadrapole Mass Spectrometers. Adv. Mass Spectrom. 1980, SB, 1764-1770. 

Thomson, B.A. Douglas, D.J. Corr, J.J. Hager, J.W. Jolliffe, C.L. Improved Collisionally Activated Dissociation Efficiency and Mass Resolution on a Triple Quadrapole Mass Spectrometer System. Anal. Chem. 1995,67,1696-1704. 

Baranov, V. (2003) Analytical approach for description of ion motion in quadrapole mass spectrometer. J. Am. Soc. Mass Spectrom., 14, 818-24. 

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