Collision activated decomposition

Figure 7. Cl MS (CH, 150 °C) generated (M+l)+ ion was quadra-pole selected and subjected to collision activated decomposition (N2) to give the mass spectrum (6).

Hunt, D.F. Shabanowitz, J. Giordani, A.B. Collision Activated Decompositions in Mixture Analysis With a Triple Quadrupole Mass Spectrometer. Anal Chem. 1980, 52, 386-390. 

Hunt, D. F., Shabanowitz, J., and Ciordani, A. B. (1980). Collision activated decomposition of negative ions in mixture analysis with a triple quadrupole mass spectrometer. Anal. Chem. 52, 386-390. 

Collision-Activated Decomposition or Collision-Induced Dissociation... 

Figure 10. Q-TOF analysis of a glycopeptide from SKPl MS-MS collision activated decomposition spectrum of m/z 829.42 + "...

Collision of normal ions from the first quadrupole with gas molecules in the second quadrupole increases fragmentation, a process known as either collisionally induced dissociation (CID) or collisionally activated decomposition (CAD). 

By CH4-chemical ionization two predominant ions from DDS were formed in the ion source m/z 163 (M + 1) and m/z 165 (M + 3), which were accelerated and separated in the first quadrupole. Decomposition by collision activation with argon then occurred in the second quadrupole and the resulting daughter ions were separated in the third quadrupole to give rise to collision-induced spectra (equations 41-43). When carrying out the analysis with a solid inlet MS-MS system (TSQ) it was observed that, when operating TSQ in the multiple ion detection mode and selecting the ions m/z 63, 83, 85,99 and 101, only in the third quadrupole was there no interference from other m/z 163 and 165 precursor ions . ... 

Collision-induced dissociation (or decomposition), abbreviated CID. An ion/neutral process wherein the (fast) projectile ion is dissociated as a result of interaction with a target neutral species. This is brought about by conversion during the collision of part of the translational energy of the ion to internal energy in the ion. The term collisional-activated dissociation (or decomposition), abbreviated CAD, is also used. 

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