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2-substituted pyrimidine-5-carboxylic esters synthesis

Enolates can also function as masked aldehydes or ketones and a new synthesis of 2-substituted pyrimidine-5-carboxylic esters 652 used a doubly masked dialdehyde 651, where one aldehyde was protected as an acetal and the other was used in the form of its sodium enolate <2002S720>. [Pg.196]

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described based on the similar concept of condensation of amidine... [Pg.574]

Hydroxy-L-prolin is converted into a 2-methoxypyrrolidine. This can be used as a valuable chiral building block to prepare optically active 2-substituted pyrrolidines (2-allyl, 2-cyano, 2-phosphono) with different nucleophiles and employing TiQ as Lewis acid (Eq. 21) [286]. Using these latent A -acylimmonium cations (Eq. 22) [287] (Table 9, No. 31), 2-(pyrimidin-l-yl)-2-amino acids [288], and 5-fluorouracil derivatives [289] have been prepared. For the synthesis of p-lactams a 4-acetoxyazetidinone, prepared by non-Kolbe electrolysis of the corresponding 4-carboxy derivative (Eq. 23) [290], proved to be a valuable intermediate. 0-Benzoylated a-hydroxyacetic acids are decarboxylated in methanol to mixed acylals [291]. By reaction of the intermediate cation, with the carboxylic acid used as precursor, esters are obtained in acetonitrile (Eq. 24) [292] and surprisingly also in methanol as solvent (Table 9, No. 32). Hydroxy compounds are formed by decarboxylation in water or in dimethyl sulfoxide (Table 9, Nos. 34, 35). [Pg.124]


See other pages where 2-substituted pyrimidine-5-carboxylic esters synthesis is mentioned: [Pg.1019]    [Pg.236]    [Pg.364]    [Pg.218]    [Pg.360]    [Pg.336]    [Pg.218]    [Pg.360]    [Pg.148]   
See also in sourсe #XX -- [ Pg.574 , Pg.575 ]




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2-substituted pyrimidine-5-carboxylic esters

Carboxylate, synthesis

Carboxylic esters syntheses

Carboxylic synthesis

Pyrimidine substituted

Pyrimidine-5-carboxylate

Pyrimidines, synthesis

Substituted carboxylic

Substituted pyrimidine synthesis

Substitution esters

Substitution synthesis

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